In cancer cells, MUC1 participates in intracellular signal transduction pathways and regulates the expression of its target genes at both the transcriptional and post-transcriptional levels. This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1.

Among them, Mucin 1 (MUC1) is widely studied for its role in the pathogenesis of various cancer types, and it is the most intensively studied transmembrane protein of the mucin family. In general, abnormal expression of the MUC1 oncogene is associated with the progression of malignant tumours.

This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.

Jun 18, 2021 · This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in …

This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1. We also discuss the recent advances made in the use of MUC1 as a biomarker and therapeutic target for cancer.

Oct 8, 1999 · Immune responses to MUC1 have been seen in breast and ovarian cancer patients and clinical studies have been initiated to evaluate the use of antibodies to MUC1 and of immunogens based on MUC1 for immunotherapy of these patients.

Nov 1, 2022 · MUC1 is a highly glycosylated transmembrane mucin on the luminal surface of epithelial cells, protecting them from extreme factors. In cancer cells, MUC1 expression is upregulated and the protein structure, glycosylation level and spatial distribution are altered.

3 days ago · As proof, MUC1 in cancer is proven to express a variety of simple and short sugar chain antigens such as Tn, sialyl-Tn, and sialyl-Lewis-X, emerging targets for cancer diagnosis and immunotherapy.

Based on these findings, a first-in-class MUC1-C inhibitor has entered Phase I evaluation as a potential agent for the treatment of patients with breast cancers that express this oncoprotein. Keywords: MUC1, breast cancer, oncoprotein, signaling pathways, targeted agents.

Mar 22, 2014 · MUC1 promotes growth, metastasis, and resistance to drugs in cancer. In tumors, the cytoplasmic tail of MUC1 acts as an oncogenic signaling molecule. MUC1 regulates gene expression at transcriptional and post-transcriptional levels. MUC1 is critical for maintaining ‘stemness’ in embryonic and cancer stem cells.