Aug 25, 2020 · Metallothionein-3 (MT3) is a representative zinc binding protein predominant in the brain. Although the role of MT3 in other organs still needs to be elucidated, many reports have suggested critical roles for the protein in the control of a variety of cellular homeostasis.

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May 11, 2023 · The brain-specific MT3 binds a mixture of Cu (I) and Zn (II) in vivo. Its metallation properties are critically important because of potential connections between Cu, Zn and neurodegenerative diseases.

Jul 7, 2023 · Mammalian zinc metallothionein-3 (Zn 7 MT3) plays an important role in protecting against copper toxicity by scavenging free Cu (II) ions or removing Cu (II) bound to β-amyloid and α-synuclein.

Jul 13, 2023 · ABSTRACT: Mammalian zinc metallothionein-3 (Zn7MT3) plays an important role in protecting against copper toxicity by scavenging free Cu(II) ions or removing Cu(II) bound to β-amyloid and α-synuclein.

The brain-specific MT3 binds a mixture of Cu (I) and Zn (II) in vivo. Its metallation properties are critically important because of potential connections between Cu, Zn and neurodegenerative diseases.

Metallothionein-3 (MT3) is one of the four mammalian metallothioneins (MT), and is constitutively synthesized in the brain. MT3 acts both intracellularly and extracellularly in this organ, performing functions related to neuronal growth and physiological metal (Zn and Cu) handling.

Mar 19, 2024 · In this paper, the Cu (I) binding properties of the apo MT1A, apo MT2, and apo MT3 are compared and the relative Cu (I) binding affinities are reported. In all three isoforms, Cu 4, Cu 6, and Cu 10 species form cooperatively, and MT1A and MT2 also form a Cu 13 species.

Human metallothioneins (MTs) are involved in binding the essential ele-ments, Cu(I) and Zn(II), and the toxic element, Cd(II), in metal-thiolate clusters using 20 reduced cysteines. The brain-specific MT3 binds a mixture of Cu(I) and Zn(II) in vivo.