Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase. It is also one of the three mitochondrial DNA (mtDNA) encoded subunits ( MT-CO1 , MT-CO2, MT-CO3 ) of respiratory complex IV .

Mar 30, 2025 · MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include Mitochondrial Complex Iv Deficiency, Nuclear Type 1 and Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes.

Mitochondrial gene COX2 methylation and downregulation is a biomarker of aging in heart mesenchymal stem cells. Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain. Novel Point Mutations in Mitochondrial MT-CO2 Gene May Be Risk Factors for Coronary Artery Disease.

In recent studies, the missense mutations in the human mt-COXI, mt-COXII, mt-ATPase6, mt-ATPase8, and genes have often been presented as pathogenic variants, since they are associated with defective mitochondrial complex IV and V, and their pathogenicity is estimated by important criteria such as the evolutionary conservation of the altered ...

Complete sequencing of the mitochondrial DNA genome in muscle identified a novel MT-CO2 variant, m.8163A>G predicting p.(Tyr193Cys). We present several lines of evidence, in proving the pathogenicity of this heteroplasmic mitochondrial DNA variant, as the cause of …

Feb 9, 2025 · Title: Mitochondrial gene COX2 methylation and downregulation is a biomarker of aging in heart mesenchymal stem cells. Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.

In particular, altered methylation and hydroxymethylation levels of mitochondrial DNA (mtDNA) have been found in animal models and in human tissues from patients affected by cancer, obesity, diabetes and cardiovascular and neurodegenerative diseases.

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

Proteintech's Rabbit Polyclonal MTCO2 antibody is validated in IF/ICC, FC (Intra) and shows reactivity with human, mouse, rat samples.

COX2/MT-CO2 Antibody recognizes endogenous levels of total COX2/MT-CO2 protein. This antibody does not cross-react with COX1/MT-CO1 or COX3/MT-CO3.