Mar 30, 2025 · MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include Immunodeficiency 14 and Cholangitis, Primary Sclerosing. Among its related pathways are Hippo-Merlin signaling dysregulation and Signaling by Receptor Tyrosine Kinases.

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene. [5] [6] [7]

Aug 28, 2013 · The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development.

Mammalian sterile 20-like kinase 1 (MST1) is a protein kinase, and the occurrence of many heart diseases is related to the continuous activation of the MST1 gene. With the deepening of the research, the potential role of MST1 in promoting the development of …

MST1 or MST2 overexpression was also found to consistently induce apoptosis; moreover, apoptosis activated the endogenous MST1/MST2 kinases, 4–9 responses suggestive of a physiologic role for these kinases in effecting apoptosis.

Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury.

MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cancer, endothelial malformations, and …

Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes. Macrophage stimulating 1-induced inflammation response promotes aortic aneurysm formation through triggering endothelial cells death and activating the NF-kappaB signaling pathway.

Jan 4, 2025 · Title: Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice. Macrophage-stimulating protein is decreased in severe preeclampsia and regulates the biological behavior of HTR-8/SVneo trophoblast cells.

Oct 28, 2008 · Yoshimura, T., Yuhki, N., Wang, M.-H., Skeel, A., Leonard, E. J. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.