MSN2 PP2A - Search

About 27,800 results

Open links in new tab

National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Yeast Protein Phosphatase 2A-Cdc55 Regulates the Transcriptional ...
We show that PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 during hyperosmolarity stress. PP2A-Cdc55 also enhances Msn2-dependent transactivation, …
- Author: Wolfgang Reiter, Eva Klopf, Eva Klopf, Veerle De Wever, Dorothea Anrather, Andriy Petryshyn, Andreas...
- DOI: 10.1128/MCB.00834-12
- Publish Year: 2013
- Publication: Mol Cell Biol. 2013 Mar; 33(5): 1057-1072.
- PP2A Phosphatase Activity Is …
  In response to stress and nutrient starvation, the Saccharomyces …
- Yeast protein phosphatase 2…
  We show that PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 …
See results only from ncbi.nlm.nih.gov
Images of Msn2 PP2A

bing.com › images
molbiolcell.org
Noise and interlocking signaling pathways promote distinct ...
researchgate.net
PP2A-Cdc55 regulates Msn2 in the nucleus. (A) Mutant cells msn2 ⌬ msn4 ...
frontiersin.org
Frontiers | Proline Homeostasis in Saccharomyces cerevisiae: How Does ...
researchgate.net
PP2A-Cdc55 regulates Msn2 in the nucleus. (A) Mutant cells msn2 ⌬ msn4 ...
researchgate.net
PP2A-Cdc55 does not dephosphorylate detectable phosphorylation sites of ...
See all
See all images
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
PP2A Phosphatase Activity Is Required for Stress and Tor Kinase ...
In response to stress and nutrient starvation, the Saccharomyces cerevisiae transcription factor Msn2p accumulates in the nucleus and activates expression of a broad array of genes. Here, …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Yeast protein phosphatase 2A-Cdc55 regulates the ... - PubMed
We show that PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 during hyperosmolarity stress. PP2A-Cdc55 also enhances Msn2-dependent transactivation, …
- Author: Wolfgang Reiter, Eva Klopf, Eva Klopf, Veerle De Wever, Dorothea Anrather, Andriy Petryshyn, Andreas...
- Publish Year: 2013
Studies of MSN2 PP2A
PubMed
Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment
We have identified Cdc55, a regulatory B subunit of protein phosphatase 2A (PP2A), as an essential activating factor for stress gene transcription in Saccharomyces cerevisiae. The presence of PP2A-Cdc55 is required for full activation of the environmental stress response mediated by the transcriptio...
Author: Wolfgang Reiter
Published: 2013/3
Keywords: National In…
febs.onlinelibrary.wiley.com
Rim15-dependent activation of Hsf1 and Msn2/4 transcription factors by direct phosphorylation in Saccharomyces cerevisiae
Rim15 kinase, a downstream effector of PKA and TORC1 signaling pathways, initiates the quiescent program upon nutrient starvation via induction of genes whose expression depends on transcription factors Msn2, Msn4, and Gis1. Here, we demonstrate that Rim15 also induces expression of Hsf1 target gene...
Author: Peter Lee, My…
Published: 15 Octobe…
Cited By: 63
PubMed
PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p
In response to stress and nutrient starvation, the Saccharomyces cerevisiae transcription factor Msn2p accumulates in the nucleus and activates expression of a broad array of genes. Here, we analyze the role of the Tor (target of rapamycin) signaling pathway in mediating these responses. Inactivatio...
Author: Arti Santhanam
Published: 2004/10
Keywords: National In…
National Center for Biotechnology Information
PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response
Tel1ATM and Mec1ATR mediate DNA damage checkpoints (Harrison and Haber, 2006) by activating the Chk1CHK1 and Rad53CHK2 kinases, which transduce the signal to downstream targets. Rad53 controls replication fork integrity and phosphorylates Dun1 to upregulate deoxy-nucleotide triphosphate (dNTP) level...
Author: Elisa Ferrari, C…
Published: 2017/07/07
Publication: Mol Cell. …
Academia.edu
https://www.academia.edu
The yeast PP2A-Cdc55 phosphatase regulates the transcriptional …
We show that PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 during hyperosmolarity stress. PP2A-Cdc55 also enhances Msn2-dependent transactivation, …
- Author: Wolfgang Reiter
- Estimated Reading Time: 9 mins
PubMed
https://pubmed.ncbi.nlm.nih.gov
PP2A phosphatase activity is required for stress and Tor kinase ...
In response to stress and nutrient starvation, the Saccharomyces cerevisiae transcription factor Msn2p accumulates in the nucleus and activates expression of a broad array of genes. Here, …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Nucleocytoplasmic Oscillations of the Yeast Transcription Factor …
Jun 19, 2007 · Coupling of Msn2 to cAMP variations is mediated through by PKA-induced phosphorylation, which promotes cytoplasmic localization of the transcription factor.
- Author: Cecilia Garmendia-Torres, Albert Goldbeter, Michel Jacquet
- Publish Year: 2007
People also ask
How is Msn2 phosphorylated?
Msn2 is directly phosphorylated by protein kinase A (PKA) on at least three amino acid residues. In glucose-grown cells, Msn2 is phosphorylated, inactive, and stress responsive. Glucose starvation causes dephosphorylation of these sites by protein phosphatase 1 (PP1) and activation of Msn2 function ( 13, 19 ).
Yeast Protein Phosphatase 2A-Cdc55 Regulates the
ncbi.nlm.nih.gov
How does MSN2/4 activate gene expression?
Msn2/4 activate gene expression by binding to stress response element (STRE, AGGGG) in response to diverse environmental stresses including heat shock, oxidative stress, and nutrient starvation [11, 12]. Gis1 activates transcription through post diauxic shift (PDS, TT/AAGGGAT) element upon glucose depletion at the diauxic shift .
Rim15‐dependent activation of Hsf1 and Msn2/4 ... - FEBS Press
febs.onlinelibrary.wiley.com
How is Msn2 phosphorylated in glucose-grown cells?
In glucose-grown cells, Msn2 is phosphorylated, inactive, and stress responsive. Glucose starvation causes dephosphorylation of these sites by protein phosphatase 1 (PP1) and activation of Msn2 function ( 13, 19 ). Nevertheless, how physical or chemical stresses stimulate Msn2 nuclear accumulation and function is still unresolved.
Yeast Protein Phosphatase 2A-Cdc55 Regulates the
ncbi.nlm.nih.gov
How does MSN2/4 regulate transcription?
Gis1 activates transcription through post diauxic shift (PDS, TT/AAGGGAT) element upon glucose depletion at the diauxic shift . Msn2/4 and Gis1 have functional overlaps, cooperatively regulating many common targets . However, it is not known how Rim15 regulates the Msn2/4-dependent transcriptional activation.
Rim15‐dependent activation of Hsf1 and Msn2/4 ... - FEBS Press
febs.onlinelibrary.wiley.com
Does Rim15 phosphorylate Msn2?
In addition, Igo1 and Igo2, Rim15 substrate proteins involved in mRNA stabilization, regulate mRNA levels of Hsf1 target genes. We also show that Rim15 can phosphorylate Msn2, but not Gis1, in vitro, implying different mechanisms for the activation of these transcription factors.
Rim15‐dependent activation of Hsf1 and Msn2/4 ... - FEBS Press
febs.onlinelibrary.wiley.com
Does hyperosmotic stress affect Msn2 expression in Cdc55 mutant cells?
Since reduced expression of the Msn2 regulon in cdc55 Δ mutant cells might be due to impaired DNA binding of Msn2 and/or RNA polymerase II complex in the mutant cells, we used chromatin immunoprecipitation (ChIP) to examine whether promoter association of Msn2 during hyperosmotic stress varied in a cdc55 Δ mutant.
Yeast Protein Phosphatase 2A-Cdc55 Regulates the
ncbi.nlm.nih.gov
Feedback
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The stress-regulatory transcription factors Msn2 and Msn4 …
In the present study, we report that the stress response transcription factors Msn2/Msn4 positively regulate β-oxidation genes under stationary-phase conditions in S. cerevisiae. Msn2/Msn4 …
FEBS Press
https://febs.onlinelibrary.wiley.com › doi › full
Rim15‐dependent activation of Hsf1 and Msn2/4
Oct 15, 2013 · Recently, it has been shown that the phosphorylated form of Igo1 binds to and inhibits Cdc55-protein phosphatase 2A (PP2A CDC55), and Gis1 was identified as one of the PP2A CDC55 targets . Therefore, Rim15 indirectly …
Taylor & Francis Online
https://www.tandfonline.com › doi › full
Yeast Protein Phosphatase 2A-Cdc55 Regulates the Transcriptional ...
We show that PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 during hyperosmolarity stress. PP2A-Cdc55 also enhances Msn2-dependent transactivation, …
nih.gov
https://www.ncbi.nlm.nih.gov › pmc › articles
PP2A Controls Genome Integrity by Integrating Nutrient-Sensing …
Jul 7, 2017 · PP2A and PP2A-like phosphatases are regulated by TORC1 (nitrogen availability), Snf1 AMPK (carbon availability), ceramide (sphingolipids and fatty acid availability), and SAM …
Pagination
- 1
- 2
- 3
- 4
- Next