MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with …

Jul 15, 2023 · What does an MSH2 mutation mean for my blood relatives? If you have a mutation, your biological parents, siblings, and children each have a 50% chance of having the same mutation. Your distant family members may also be at risk for having the same mutation.

The MSH2 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division.

Mar 24, 2025 · MSH2 inherited mutations (Lynch Syndrome) may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

Understanding Your Positive MSH2 Genetic Test Result information for patients with a pathogenic or likely pathogenic variant There is a 50/50 random chance to pass on the pathogenic or likely pathogenic MSH2 variant to each of your children. MSH2 Lifetime Cancer Risks* MSH2 in the Family Has pathogenic or likely pathogenic MSH2 variant No ...

Mar 30, 2025 · MSH2 (MutS Homolog 2) is a Protein Coding gene. Diseases associated with MSH2 include Lynch Syndrome 1 and Muir-Torre Syndrome. Among its related pathways are DNA repair pathways, full network and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.

Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pathogenic germline variants in the DNA mismatch repair (MMR) genes MSH2, MSH6, MLH1, and PMS2. The aim of this study was to ...

Aug 23, 2022 · Finding out you have an MSH2 gene mutation can be useful information for your family members. It can also help you better understand your cancer risk. Men and women with an MSH2 mutation have...

Mar 24, 2025 · MSH2 mutations increase the risk for colorectal, endometrial and other types of cancer listed in the table below. Experts at the National Comprehensive Cancer Network (NCCN) created guidelines which estimate the cancer risks for people with MSH2 mutations.

MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1. Comprehensive RNA and protein functional assessments contribute to the clinical interpretation of MSH2 variants causing in-frame splicing alterations. hMSH2 coordinated with the expression of E2F1 promotes platinum response in epithelial ovarian cancer.