May 15, 2015 · ROS are short-lived oxygen-containing molecules that display high chemical reactivity toward DNA, RNA, proteins, and lipids. Mitochondrial complexes I and III, and the NADPH oxidase isoform NOX4 are major sources of ROS production during MSC differentiation.

ROS are short-lived oxygen-containing molecules that display high chemical reactivity toward DNA, RNA, proteins, and lipids. Mitochondrial complexes I and III, and the NADPH oxidase isoform NOX4 are major sources of ROS production during MSC differentiation.

Sep 17, 2020 · Finally, we discovered that AS serum-induced mitochondrial dysfunction resulted in elevated reactive oxygen species (ROS) in MSCs, and ROS inhibition successfully rescued MSCs from senescence.

Through intercellular mitochondria trafficking, modulation of ROS, and modification of nutrient bioavailability, endogenous MSCs and MSC therapies are believed to exert protective effects by regulation of cellular metabolism in injured tissues.

In this review, we focus on the currently revealed ROS generation mechanisms and the regulatory routes for controlling their rates of proliferation, survival, senescence, apoptosis, and differentiation.

Jun 17, 2022 · Levels of antioxidant proteins were investigated via immunoblotting. Co-culturing of complex I-deficient fibroblast with MSCs lowered cellular ROS levels. The effect on ROS production was more sustained compared to treatment of patient fibroblasts with culture medium derived from MSC cultures.

Apr 1, 2022 · The MSCs-laden RCGel (MSC/RCGel) is firstly characterized to explore the effects of RCGel encapsulating on MSCs to withstand ROS injury and its role in rescuing cardiomyocytes under oxidative or hypoxia conditions in vitro.

Oct 14, 2020 · In the present study, we examined the correlation between aging and the expression of ROS in human adipose tissue-derived (AT-) MSCs and the cellular functions by comparing AT-MSCs derived from...

Jun 30, 2021 · High levels of reactive oxygen species (ROS) are produced during isolation, cell culture, and transplantation lead to OS, which induces cell death and apoptosis and limits the efficacy of their regeneration capability.

Jun 3, 2020 · Data show that sublethal ROS and ionizing radiation can cause DNA damage to MSCs derived from human umbilical cord. The increased intracellular ROS is an important cause of senescence of bone marrow-MSCs (BM-MSCs) that show reduced DNA synthesis and cell proliferation and consequent cell senescence .