Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix.

Jul 9, 2021 · Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling.

May 15, 2020 · MMP-9 is one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to degrade the extracellular matrix (ECM) components and has important role in the pathophysiological functions. Overexpression and dysregulation of MMP-9 is associated with various diseases.

Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling.

As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It ...

Aug 22, 2021 · MMP-9 is an important marker of intestinal inflammation. It has been shown to be significantly increased in the stool of UC patients compared with healthy controls and patients with IBS, and was found to correlate with the clinical and endoscopic activity of UC.

Jul 13, 2022 · MMP-9 is an enzyme that has been linked to signs of inflammation on the surface of the eye that may be causing you discomfort. A test can check levels of MMP-9 enzyme if your eye doctor (ophthalmologist or optometrist) suspects you have dry eye or is trying to determine how to best treat it.

MMP-9 is a marker of inflammation, tissue remodeling, wound healing, and mobilization of tissue-bound growth factors and cytokines. Its expression correlates with abnormal collagen deposition accompanying pancreatic cancer, with lymph node metastasis in breast cancer and with regional vessel invasion by giant cell tumor or bone.

MMP-9, a member of the gelatinase B family, is characterized as one of the most intricate MMPs. The crucial involvement of MMP-9 in extracellular matrix (ECM) remodeling underscores its significant correlation with each stage of cancer pathogenesis and progression.

High levels of Matrix Metalloproteinase-9, or MMP-9, in your body could indicate that your body is working overtime to repair or remodel tissues, which is often a response to inflammation or tissue damage. This can be seen in a variety of health conditions.