Among the MMPs, MMP-14 is the driving force behind extracellular matrix and tissue destruction during cancer invasion and metastasis. MMP-14 also influences both intercellular as well as cell–matrix communication by regulating the activity of many plasma membrane-anchored and extracellular proteins.

Matrix metalloproteinases (MMPs) are a family of secreted, zinc-dependent endopeptidases collectively capable of degrading ECM components, and there is a considerable amount of evidence that they play an important role at different steps of malignant tumor growth. Recent observations also suggest that MMPs play a role in cancer cell survival.

Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM. The degradation of the ECM is of great importance, since it is related to embryonic development and angiogenesis.

Matrix metalloproteinases have been linked to a wide variety of pathological states including carcinogenesis. The association between different members of the MMP family and cancer suggests that their inhibition could profoundly impact the suppression of …

Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor cells and stromal cells, are finely regulated by their spatial as well as temporal interactions with distinct cellular and extracellular components of the tumor microenvironment and …

Jun 14, 2019 · By understanding Matrix Metalloprotease (MMP) dysregulation from a pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across multiple neoplasms. MMPs are intriguing genes related to cancer disease progression, functional promotion of angiogenesis, invasion, metastasis, and avoidance of immune surveillance.

DX-2400 is a high-affinity, highly selective inhibitor of MMP-14 that retards tumor growth and metastasis in several in vivo mouse models of breast cancer and melanoma, both as single agent and in combination with paclitaxel or bevacizumab.

Jan 18, 2023 · Matrix metalloproteinases (MMPs) are the most prominent proteinases involved in tumorigenesis. They were initially recognized to promote tumor progression by remodeling the extracellular matrix through their proteolytic activity.

Dec 23, 2021 · Among the MMPs, MMP-14 is the driving force behind extracellular matrix and tissue destruction during cancer invasion and metastasis. MMP-14 also influences both intercellular as well as cell-matrix communication by regulating the activity of many plasma membrane-anchored and extracellular proteins.

The matrix metalloproteinases (MMP) are a family of proteolytic enzymes that degrade multiple components of the extracellular matrix. A large body of experimental and clinical evidence has implicated MMPs in tumor invasion, neoangiogenesis, and metastasis, and therefore they represent ideal pharmaco …