Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.

Dec 1, 2021 · We will first discuss the basic biochemistry and regulation of MKP-1. Next, we will present the current consensus on the immunological and physiological functions of MKP-1 in infectious, inflammatory, metabolic, and nervous system diseases as …

Aug 10, 2017 · Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation.

Herein, we show that TNFα increases MKP-1 mRNA expression and protein upregulation in a p38 MAPK-dependent manner. TNFα does not increase MKP-1 transcription (measured by MKP-1 promoter activity); rather, we found that TNFα-induced MKP-1 mRNA stability is regulated by the p38 MAPK pathway.

In MKP-1, MAPK binds to the active site that is between the CH2A and CHB domains located in the N-terminal. [ 21 ] [ 22 ] An example of a type II MKP is MKP-3 which, regulates the activity of ERK2 by deposphorylating it and holding it in the cytoplasmic region. [ 23 ]

Mar 1, 2024 · Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a negative regulator of MAPK signaling pathways involved in cellular stress responses, survival, and neuroinflammation.

MKP-1 is a critical counter-regulator of MAPK signaling in monocytes and macrophages. MKP-1 regulates monocyte adhesion and migration. MKP-1 regulates macrophage activation, inflammatory responses and survival. MKP-1 activity is regulated at the level of transcription, translation and by posttranslational modifications. Acknowledgments. FUNDING

Jan 1, 2020 · Mitogen-activated protein kinase (MAPK) § cascades are crucial signaling pathways in the regulation of the host immune response to infection. MAPK phosphatase (MKP)-1, an archetypal member of the MKP family, plays a pivotal role in the down-regulation of p38 and JNK.

Feb 13, 2012 · We will first discuss the basic biochemistry and regulation of MKP-1. Next, we will present the current consensus on the immunological and physiological functions of MKP-1 in infectious, inflammatory, metabolic, and nervous system diseases as …

Mar 1, 2006 · Four independent papers published recently describe a role for MAPK phosphatase 1 (MKP1; also known DUSP1) — which dephosphorylates MAPKs — as a key negative regulator of TLR-induced...