In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). Class II HLAs are composed of the classical HLA-DP, HLA-DQ, and HLA-DR and non-classical HLA-DM and HLA-DO MHC molecules.

Feb 27, 2015 · Nonspecific endocytosis processes are terminated following dendritic cell (DC) activation, but mature DCs can still internalize antigen by receptor-mediated endocytosis or phagocytosis. Using...

Here we present an illustrated review on the ins and outs of MHC class I and MHC class II antigen presentation. Keywords: Antigen Presentation, MHC class I, MHC class II, tumor immunology, transplantation, auto-immune diseases. Why Do We Need to Present Antigens?

Oct 1, 2005 · MHC-class-II-mediated peptide presentation is essential for positive and negative selection of CD4 + T cells in the thymus, for homeostasis of the mature CD4 + T-cell population in the...

Dec 12, 2008 · We found that the major histocompatibility complex II–associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo.

Dec 22, 2013 · CD11b + dendritic cells (DCs) seem to be specialized for presenting antigens via major histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and regulatory...

Jun 1, 2001 · We have investigated the mechanisms that control MHC class II (MHC II) expression in immature and activated dendritic cells (DC) grown from spleen and bone marrow precursors.

May 20, 2021 · MigDCs from HPV mice (migDC HPV) showed lower MHC2 levels than migDC WT (Figure 7A-B), consistent with previous reports. 59,60 ResDC HPV and pDC HPV also showed lower MHC2 levels than their controls (Figure 7B-C), highlighting a systemic effect of HPV-induced inflammation on DC-subset activation.

In this Review, we describe our current knowledge of the mechanisms of uptake and processing of antigens, the intracellular formation of peptide–MHC class II complexes, the intracellular trafficking of peptide–MHC class II complexes to the APC …

Dendritic cells (DCs) and B cells present antigen-derived peptides bound to MHC class II (MHC II) molecules for recognition by CD4-positive T lymphocytes. DCs control the intracellular traffic of peptide–MHC II complexes by regulating the ubiquitination of MHC II.