CD8+ T cells maintain killing of MHC-I-negative tumor cells
Aug 3, 2023 · Fecci and colleagues show that tumor cells having lost MHC-I, a major mechanism of immune escape, are amenable to killing by CD8+ T cells through an MHC-I-independent, …
CD8+ T cells maintain killing of MHC-I-negative tumor cells …
Fecci and colleagues show that tumor cells having lost MHC-I, a major mechanism of immune escape, are amenable to killing by CD8 + T cells through an MHC-I-independent, alternative …
CD8+ T cells maintain killing of MHC-I-negative tumor cells
The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell killing by CD8 + T cells recognizing cognate antigens presented in the context of target cell major …
CD8+ T cell killing of MHC class I–deficient tumors - Nature
Aug 3, 2023 · CD8 + T cells recognize tumor-associated antigens presented by major histocompatibility complex (MHC) class I molecules. How CD8 + T cells eliminate cancer cells …
Cytotoxic CD8+ T cells in cancer and cancer immunotherapy
Sep 15, 2020 · CD8 + T cells interact with major histocompatibility complex class-1 (MHC-1) molecules 6 on the surface of antigen-presenting cells (APCs) and target cells, which display …
The comings and goings of MHC class I molecules herald a new …
MHC class I (MHC-I) molecules are the centerpieces of cross-presentation. They are loaded with peptides derived from exogenous sources and displayed on the plasma membrane to …
New insights on anti-tumor immunity of CD8
Mar 17, 2025 · Cytotoxic T cells, or CD8 + T cells detect tumor or infected cells by binding their T cell receptor (TCR), specifically to the MHC class I peptide complex. Effector CD8 + T cells …
Distinct CD8+ T cell dynamics associate with response to …
Mar 13, 2025 · Li et al. analyze CD8+ T cells collected from HNSCC patients treated with neoadjuvant immunotherapies. They show that different combination immunotherapies …
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 …
In this study, we used a panel of MHCI mutants with altered CD8-binding properties to show that TCR-mediated antigen specificity is delimited by a pMHCI/CD8 affinity threshold.
Molecular interactions of coreceptor CD8 and MHC class I: the …
Dec 1, 2000 · Here, we review the structural, mechanistic and functional studies that point to a model of coordination of T-cell receptor and CD8 signaling that might provide the key to …