Mar 1, 2024 · Furthermore, we discovered cediranib achieved MHC-I upregulation through transcriptional regulation. interferon regulatory factor 1 (IRF-1) was required for cediranib induced MHC-I transcription and the absence of IRF-1 eliminated this effect.

May 1, 1997 · Transcription factor interferon regulatory factor-1 (IRF-1) is implicated in regulating class I MHC expression in vitro. We investigated the in vivo relationship between IRF-1 and MHC expression in kidney and other nonlymphoid organs, assessing MHC expression in mice with disrupted IRF-1 genes (IRF- …

Jan 1, 2002 · The present studies demonstrate conclusively that IRF-1 plays a major role in expression of MHC class I genes in neural cells in response to IFN-γ and that MHC-IRF-E/IRF-1 interactions are important in controlling IFN-γ-induced promoter activity.

This transcriptional regulation of IRF-1 gene by IFN-gamma and TNF-alpha was confirmed at the mRNA level. The synergism demonstrated in the present study highlights the importance of cytokine interactions in magnifying their biological effects during brain injury and inflammation.

Feb 28, 2025 · IRF-1 is a key transcription factor in the interferon signaling response and is also another critical transcription factor for the expression of MHC I. When IFN-γ binds to its receptor, it stimulates the phosphorylation of Janus kinases JAK1 and JAK2, which subsequently phosphorylate STAT1.

MHC class I antigen presentation-associated gene expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-gamma binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via phosphorylation of JAK and STAT1 in cells.

We have investigated the role of interferon regulatory factor-1 (IRF-1), an interferon-γ (IFN-γ) inducible transcriptional activator, on major histocompatibility complex (MHC) class I gene transcription.

Type I IFN (IFN-alpha/beta) are expressed in many cell types early after primary viral infection and have been shown to mediate resistance against a variety of viruses. In this study, the role of the transcriptional activator IFN regulatory factor-1 …

Recent studies have shown that the role of the transcription factor interferon regulatory factor-1 (IRF-1) in the expression of major histocompatibility complex (MHC) class I molecules is tissue-specific. Our previous studies indicated a role for IRF-1 in expression of MHC class I genes in cultured astrocytes in response to interferon-γ (IFN-γ).

Recent studies have shown that the role of the transcription factor interferon regulatory factor-1 (IRF-1) in the expression of major histocompatibility complex (MHC) class I molecules is tissue-specific.