Human cytomegalovirus (HCMV) infection remains a significant global health challenge, particularly for immunocompromised individuals and newborns. This comprehensive review …

HCMV infections show low pathogenicity in healthy, immunocompetent individuals and cause only mild, if any, symptoms. HCMV leads to latent (persistent) infections with the possibility of …

Mar 17, 2020 · We investigated the impact of HCMV infection on MHC class II in Kasumi-3 cells, a myeloid-progenitor cell line that endogenously expresses the MHC class II gene, HLA-DR. We …

Human cytomegalovirus (HCMV) causes lifelong, persistent infections and its survival is under intense, continuous selective pressure from the immune system. A key aspect of HCMV’s …

Jan 19, 2011 · The increased portion of endo H-sensitive MHC I molecules in HCMV-infected cells supports the assumption that MHC I is trapped in the ER, ERGIC, and/or cis-Golgi …

Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes lifelong infection in humans. HCMV has a prevalence of 55-100% within the human population, depending on different …

Jul 1, 2002 · CD8(+) and CD4(+) T lymphocytes are important in controlling human CMV (HCMV) infection, but the virus has evolved protean mechanisms to inhibit MHC-based Ag presentation …

Mar 12, 2025 · This protein complex, formed by the five glycoproteins UL128, UL130, UL131A, gH, and gL (13–16), is conserved across all known primate CMVs.For HCMV, binding of the …

Two HCMV proteins, US2 and US11, target newly synthesized MHC class I heavy chains for destruction via a pathway that involves ubiquitin-dependent retrograde transport, or …

Mar 3, 1998 · Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that is able to persist for decades in its host. HCMV has evolved protean countermeasures for anti-HCMV cellular …