The combined organic phase was dried (Na 2 SO 4) and the solvent removed under reduced pressure to afford 1- (1,3-benzodioxol-5-yl)-2-propanone (MDP2P) (yield 30%, 1.32 g) as a light brown oil. 1H NMR: 2.14 (s, 3H, CH 3 ), 3.59 (s, 2H, CH …

Aug 17, 2024 · In this study, the keto-enol tautomerism of four 1,3-dicarbonyl drug pre-precursors, α -phenylacetoacetamide (APAA), methyl α -phenylacetoacetate (MAPA), ethyl α-phenylacetoacetate (EAPA), and methyl 2- (benzo [d] [1,3]dioxol-5-yl)-3-oxobutanoate (MAMDPA) were investigated through NMR.

Dec 20, 2021 · A sample of prepared piperonal was successfully converted into MDMA via 3,4-methylenedioxyphenyl-2-nitropropene (MDP2NP) and 3,4-methylenedioxyphenyl-2-propanone (MDP2P) and the impurities within each product characterised by GC-MS to give a contaminant profile of the synthetic pathway.

May 27, 2004 · In a first step, diazomethane reacts with piperonal yielding the expected 3.4-methylenedioxyacetophenone. The latter can react further with more diazomethane giving (theoretically) a mixture of MDP1P and MDP2P. Aryl migration is prefered, so MDP2P forms the major product (and MDP1P the minor).

In our study 1-(3,4-methylenedioxyphenyl)-2-propanone (MDP-2-P or PMK) was prepared by two different routes, i.e. by oxidizing isosafrole in an acid medium and by 1-(3,4-methylenedioxyphenyl)-2-nitropropene reduction. The final product-MDP-2-P was subjected to GC/MS analysis.

trans-anethole oxide and trans-asarone oxide were found to have very pure NMR spectra with little or no impurity peaks.

Aug 17, 2024 · The application of 1,3-dicarbonyl precursors as alternative precursors for the synthesis of 1-phenyl-2-propanone (P2P) and 3,4-methylenedioxyphenyl-2-propanone (MDP2P) has created new challenges to legal control.

Mar 1, 2015 · Safrole was then converted to 3,4-methylenedioxyphenyl-2-propanone (MDP2P) using two synthetic methods: Wacker oxidation (Route 1) and an isomerisation/peracid oxidation/acid dehydration method (Route 2). MDMA was then synthesised by reductive amination of …

There has been a significant amount of research into the organic impurity profiles of MDMA synthesised from the most common precursors: 3,4-methylenedioxyphenyl-2-propanone (MDP2P), safrole, isosafrole and piperonal [3]. These precursors, however, are controlled or regulated substances in many jurisdictions.

methylenedioxyphenyl-2-propanone (MDP2P) can be produced. MDMA can then be produced from MDP2P. Any changes seen in stable isotope ratios during this pathway can be utilised when attempting to explain batch-to-batch variations and provide tactical intelligence information for seized samples.