Apr 16, 2004 · Here we provide evidence supporting functional interaction between MDM2 and p21 in vitro and in vivo. The inhibition of MDM2 with anti-MDM2 antisense oligonucleotide or …

MDM2 shortened the half-life of both exogenous and endogenous p21 waf1/cip1 by 50% and led to the degradation of its lysine-free mutant. Consequently, MDM2 suppressed p21 waf1/cip1 …

Dec 1, 2003 · MDM2 shortened the half‐life of both exogenous and endogenous p21 waf1/cip1 by 50% and led to the degradation of its lysine‐free mutant. Consequently, MDM2 suppressed …

This version of p21 was capable of interacting with cyclin-dependent kinase 2 (Cdk2) but failed to inhibit its activity. Taken together, these results argue that Mdm2 is needed for full inhibition of …

MDM2 facilitates p21 degradation independent of ubiquitination and the E3 ligase function of MDM2. Instead, MDM2 promotes p21 degradation by facilitating binding of p21 with the …

Following cellular stress, p53 induces the expression of the cyclin-dependent kinase (cdk) inhibitor p21, among other target genes. p21 is a key mediator of arrest at the G 1 phase of the cell …

MDM2 binds to p21 and promotes p21 proteasomal degradation . We assessed MDM2 involvement in the fluoride-mediated decrease of p21 protein levels observed at 24 h. The co …

May 10, 2019 · These results suggest that MDM2-mediated p21 proteasomal degradation with subsequent phospho-p21 attenuation contributes to fluoride-induced apoptosis. Inhibition of …

Jun 11, 2010 · MDM2 and p21 Waf1 co-localize in the nucleus, and mutations to the NLS, NES, and AD of MDM2 prevent its degradation of p21 Waf1. HCT116 (p53 −/−) cells were grown on …

Mar 3, 2009 · We uncovered that MDM2 released from p53 by RITA promotes degradation of p21 and the p53 cofactor hnRNP K, required for p21 transcription. Functional studies revealed …