Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. [5] [6] Mdm2 is an important negative regulator of the p53 tumor suppressor.

Mar 30, 2025 · MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Transport of the SLBP independent Mature mRNA.

May 13, 2024 · This review presents a comprehensive overview of the molecular characteristics of MDM2 and the current state of research on MDM2-targeting inhibitors. It includes a review of the impact of MDM2 targeting on the efficacy of immunotherapy, providing guidance and direction for the development of drugs targeting the p53-MDM2 interaction and ...

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53, playing a key role in controlling its transcriptional activity, protein stability, and nuclear localization. MDM2 expression is up-regulated in numerous ...

Jun 5, 2009 · A key Mdm2 function is to promote ubiquitylation and proteasomal-dependent degradation of the tumor suppressor protein p53.

MDM2 binds the transactivation domain of p53 and inhibits the ability of p53 to activate transcription. Importantly, MDM2 binding also promotes the ubiquitin-mediated degradation of p53, as well as the export of p53 from the nucleus to the cytoplasm.

Dec 1, 2003 · The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor suppressor. Amplification of mdm2 or increased expression by unknown mechanisms occurs in many tumors. Thus, increased levels of MDM2 would inactivate the apoptotic and cell cycle arrest functions of p53, as do deletion or mutation of p53, common events in the ...

Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, ...

Jul 10, 2020 · MDM2 then inhibits the p53-mediated transcription of MDM2 and other downstream target genes by binding to p53, blocking its transactivation domain. Through E3 ubiquitin ligase activity, MDM2...

MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2betacc in a p53-independent manner. SRSF7 downregulation induces cellular senescence through generation of MDM2 variants. MDM2-p53 mediate a miR-181c-3p/LIF axis to regulate low dose-rate radiation-induced DNA damage in human B lymphocytes.