MDA5 disease variant M854K prevents ATP-dependent structural ... - Nature
Nov 18, 2021 · We show that the M854K mutation abrogates ATPase activity, stabilizes MDA5-dsRNA complexes, increases IFN-β transcription, and dampens the cooperativity of signal …
MDA5 - Wikipedia
MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like …
Activation of MDA5 Requires Higher-Order RNA Structures …
Recognition of virus presence via RIG-I (retinoic acid inducible gene I) and/or MDA5 (melanoma differentiation-associated protein 5) initiates a signaling cascade that culminates in …
MDA5 cooperatively forms dimers and ATP-sensitive filaments …
Melanoma differentiation-associated gene-5 (MDA5) detects viral double-stranded RNA in the cytoplasm. RNA binding induces MDA5 to activate the signalling adaptor MAVS through …
A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation
MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of viruses, including picornaviruses. Recent work showed …
Activation of MDA5 requires higher-order RNA structures …
Recognition of virus presence via RIG-I (retinoic acid inducible gene I) and/or MDA5 (melanoma differentiation-associated protein 5) initiates a signaling cascade that culminates in …
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA …
Nov 22, 2024 · MDA5 is a RIG-I–like receptor that binds long paired dsRNA, including from specific types of viruses, and then activates mitochondrial antiviral-signaling protein (MAVS) …
The RNA sensor MDA5 detects SARS-CoV-2 infection
Jul 1, 2021 · We report that the cytosolic RNA sensor MDA5 was required for type I and III IFN induction in the lung cancer cell line Calu-3 upon SARS-CoV-2 infection.
Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS …
The RNA sensor MDA5 recruits the signaling adaptor MAVS to initiate type I interferon signaling and downstream antiviral responses, a process that requires K63-linked polyubiquitin chains. …
An arms race under RIG-I loss: 5’ppp-RNA and its alternative
Jan 24, 2024 · Results demonstrated that MDA5 detection of RNA in RIG-I deficient vertebrates is guided by the RNA 5’-triphosphate and is disrupted when RNA is capped at the 5’ …