MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old woman. [1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [2]

Chromosome 20 was nullisomic and X was disomic. The MCF7 line retains several characteristics of differentiated mammary epithelium including ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. The cells express the WNT7B oncogene.

Among many cell lines, the MCF-7 line has been widely used in in vitro breast cancer research worldwide for many years. It is positive for estrogen (ER), progesterone (PR), human epidermal growth (HER2), EGFR, and E-cadherin.

Apr 26, 2012 · MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27].

MCF-7 and MCF-10 are both cell lines used in breast cancer research, but they have distinct characteristics. MCF-7 cells are derived from metastatic breast adenocarcinoma tissue and are tumorigenic, while MCF-10 cells are derived from normal breast …

The current paper provides a broad description of the MCF-7 cell line, including the molecular profile, proliferation, migration, invasion, spheroid formation, its involvement in angiogenesis and lymphangiogenesis and its interaction with the mesenchymal stem cells.

Mar 31, 2015 · MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes.

Oct 1, 2019 · Here, we report how the ER + cell line MCF-7 can be used to dissect risk mechanisms for breast cancer. According to the traditional model of carcinogenesis, normal tissue undergoes rounds of oncogenic mutations during proliferation that eventually leads to …

We have recently developed a protocol for MCF-7 cell spheroid culture, and used this method to test the effects of different types of drugs on this estrogen-dependent breast cancer cell spheroid. Our results demonstrated that MCF-7 cells can grow spheroid in …

Apr 4, 2012 · Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12584. Registration: Chiron Master Culture Collection; CMCC 10377 (CMCC …