Feb 28, 2022 · We modeled loss of function (LOF) in four common anti-PD-1 antibody-responsive syngeneic tumors, MC38, Hepa1-6, CT-26 and EMT-6, by systematical depleting a series of TIL lineages to explore...

Apr 20, 2023 · Aside from the phenotypic features of T cell infiltration in MC38 tumours, this study also characterised the frequency of CD8 + TILs responsive to peptide stimulation with tumour antigens (TAs) identified in the MC38 model.

Dec 6, 2022 · In this Article, we engineered mesenchymal stem cells (MSCs) with tumour-targeted adjustable delivery of SIL2, a super IL-2 mutein dimer, to preferentially activate CD8 + TILs.

Accordingly, anti-PD-1 and anti-PD-L1 each activated CD8 + TILs in MC38, B16-SIY, and A20-OVA organoids, prominently stimulating Ifng, Prf1, and Gzmb mRNA (Figure 6C) even after cryopreservation and recovery (Mendeley Figure 10).

Jul 7, 2020 · In this study, we show that a local injection of oncolytic poxvirus in MC38 tumor with low immunogenicity in C57BL/6 mice, led to elicitation and accumulation of tumor-specific TILs in the...

Sep 11, 2023 · Indeed, we detected lower TOX protein in PD-1 + TIM-3 + TILs in MC38-OVA as compared to B16-OVA tumors (Figure 7B). Accordingly, we also found that highly immunogenic Yummer 1.7 melanomas harbored low TOX + PD-1 + TIM-3 + TILs, indicating that reduced accumulation of TOX + dysfunctional cells is a feature of highly immunogenic tumors ( Figure ...

Mar 14, 2016 · To address the role of TILs for checkpoint blockade responsiveness, we sought two strategies to test: (1) whether a reduction of TILs in MC38 will diminish its response to PD-L1 blockade, and (2) whether an increase in TILs in Ag104Ld will …

TILs harvested from early MC-38 adenocarcinoma tumors (days 9 and 20 post-tumor implantation), demonstrated significantly higher cytotoxicity against a variety of tumor targets compared to older TILs (days 31 and 37).

In this case study, we will build an integrated scRNA-seq analysis workflow to interpret the transcriptional and clonal structure of tumor-infiltrating T cells in MC38 colon adenocarcinoma …

Apr 9, 2025 · TILs clustered in 13 subsets (Fig. 6c) that were annotated on the basis of classical T cell marker expression 52, the most deregulated genes per cluster (Supplementary Fig. 6a-c), cross-labeling ...