MC38 colon adenocarcinoma is a widely used preclinical model, yet how it recapitulates human colorectal cancer remains poorly defined. This study investigated the tumour-T cell immune …

Immunohistochemistry of MC38 Tumors: Detection of CD3+ T Cells and PD-L1+ Cells on the Tumor Perimeter and Interior. C57BL/6 mice bearing MC38 tumors (n = 4–5 mice/group) were …

Feb 13, 2023 · Immunohistochemistry (IHC) with anti-GFP or anti-S100A4 antibodies tracing of Mc38 cells in varied stages showed a replacement growth pattern of CRLM (A) and positive …

Mar 1, 2022 · Trichrome and immunohistochemistry (IHC) staining of MC38 tumors with biotinylated NC410 demonstrated high collagen content and binding of NC410 to collagen-rich …

Jan 24, 2020 · Using an engineered CD73-MC38 murine CRC model, we further demonstrate that the collaborative effects of andenosinergic antagonism and CD73-neutralization on tumor …

The cell line MC38 is a commonly used murine model for colorectal carcinoma. It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and endogenous CD8+ …

Oct 6, 2021 · MSLN-TTC showed strong antitumor activity (T:C 0.38, p<0.05) as a single agent in human MSLN-expressing MC38 tumor-bearing immunocompetent mice. Combining MSLN …

Spatial organization of immune cells in subcutaneous MC38 tumours Representative micrographs of H&E and indicated IHC stains of subcutaneous MC38 tumours. Arrows indicate positive …

RNA sequencing of MC38 model tumors showed that multiple immune responses were activated after combination therapy, including improved interferon-γ (IFN-γ) response and MHC-I …

CD8+ T-cell proliferation was quantified by the level of CFSE dilution by flow cytometric analysis, normalized to controls (T cells stimulated in the absence of Tregs). S1 Tumor growth analysis …