Fas signaling in adipocytes promotes low-grade inflammation …
Dec 1, 2021 · We established an MC38 colon cancer cell lung metastasis model for Fas overexpression in male adipocytes (Fas CKI/CKI×Adi-cre) and littermates (Fas CKI/CKI) after …
Loss of Fas Expression and Function Is Coupled with Colon Cancer ...
CD133 + CD24 lo Fas lo cells exhibited significantly higher lung colonization potential in both the CT26 (Fig. 6B) and MC38.met (Fig. 6D) mouse models. This increased invasiveness is …
Fas signaling in adipocytes promotes low-grade inflammation …
Dec 1, 2021 · In this study, we found that the increased tumor necrosis factor-alpha (TNF-α) in adipocytes promoted the lung metastasis of MC38 colon cancer cells via Fas signaling.
Irradiation of tumor cells up-regulates Fas and enhances CTL lytic ...
Jun 15, 2003 · Treatment of carcinoembryonic Ag-expressing MC38 adenocarcinoma cells with irradiation (20 Gy) in vitro enhanced Fas expression at molecular, phenotypic, and functional …
Human and mouse colon cancer utilizes CD95 signaling for local …
Here we use the well described murine colon cancer cell line MC38 to address the role of Fas Ag, Fas L and Fas apoptosis resistance in the behavior of colon cancer cells. We demonstrate that …
The Nlrp3 Inflammasome Suppresses Colorectal Cancer ... - Cell …
Oct 20, 2015 · To investigate the role of the inflammasome in liver CRC metastasis, we implemented a model of intrasplenic injection of transplantable tumor cells derived from a …
Local Irradiation Sensitized Tumors to Adoptive T Cell Therapy via ...
Here, we found that dose-dependent increase in Fas expression was induced by irradiation in both MC38-OVA cells and EG7-OVA cells. Correspondingly, in established MC38-OVA and …
Reprogramming immunosuppressive myeloid cells by activated …
Jan 8, 2021 · To confirm the role of reprogramming MDSCs by activated T cells in vivo, we tested the effect of PD-1 mAb on the survival and function of tumor-infiltrating myeloid cells in an ICB …
Oncolytic poxvirus armed with Fas ligand leads to induction of …
Nov 25, 2011 · Infection of FasR+ normal and MC38 cancer cells by vFasL led to abortive viral replication owing to acute apoptosis and subsequently showed both reduced pathogenicity in …
| Irradiation increased tumor cell sensitivity to OT-I T cell-mediated ...
Our results showed an increase in the lysis of MC38-OVA and EG7-OVA cells at the indicated E:T ratio (Figures 5A,B). Conversely, irradiation failed to increase the lysis of the MC38 and EL-4...