Mar 15, 2023 · Here, we report a novel immune molecule, CD43, that can regulate the tumor immune microenvironment (TIME) and serves as a promising target for CRC immunotherapy. The correlation of CD43 expression with CRC patient prognosis was revealed by public data analysis.

Apr 18, 2023 · Using an antibody to the hyperglycosylated form of CD43 (clone 1B11 8), the authors were able to study the temporal dynamics of CD43-1B11 + T cells within the circulation of mice with MC38 tumors.

Sep 19, 2024 · CD38 enzymatic and receptor inhibition regulated CD43 and galectin-1 expression, CD45 activity hi populations, and CLL proliferation, while leaving Th cells largely unaffected.

Jan 2, 2018 · Of the 2743 amino-acid changes (missense and stop codon) in MC38, 1399 neoantigens were predicted to strongly bind to the C57Bl/6 major histocompatibility molecules (MHC) class I molecules H2-K b...

In this paper, we reviewed the role and mechanism of CD38 + CD4 + T cells / CD38 + CD8 + T cells in cellular immunity and the effects of the CD38-NAD + axis on T cell activity.

Apr 16, 2020 · We performed scRNA-seq analyses on immune and stromal populations from colorectal cancer patients, identifying specific macrophage and conventional dendritic cell (cDC) subsets as key mediators of cellular cross-talk in the tumor microenvironment.

Mar 1, 2019 · The MC38 murine colon carcinoma model can be employed as a robust preclinical immuno-oncology model. Our data supports the use of this tool in investigating novel treatment combinations with radiation, checkpoint inhibitors, costimulatory molecules, …

The cell line MC38 is a commonly used murine model for colorectal carcinoma. It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and endogenous CD8+ T cell responses against neoantigens have been reported. Here, we ...

Loss of CD43 facilitated the infiltration of immune cells and immunological memory in the TIME of CRC tumors. Mechanistically, the protumor efect of CD43 depends on T cells, thereby attenuating T-cell-mediated cytotoxicity and cDC1-mediated antigen-specific T-cell activation.

Here, we profiled the tumor infiltrating lymphocyte (TIL) landscape in response to combination checkpoint blockade at two distinct timepoints of solid tumor growth. Methods: C57BL/6 mice bearing subcutaneous MC38 tumors were treated with anti-PD-1 and/or anti-CTLA-4 antibodies.