DLin-MC3-DMA: An ionizable cationic lipid. CAS Number: 1224606-06-7. Synonyms: Dilinoleyl-methyl-4-dimethylaminobutyrate, MC3. Purity: ≥95%.

Dec 13, 2021 · Later, they demonstrated that an alkyne ionizable lipid (A6) could greatly increase membrane fusion and facilitate albumin-mediated mRNA delivery when incorporated into benchmark LNPs (e.g., MC3)...

Aug 10, 2021 · In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle–mRNA systems.

DLin-MC3-DMA (MC3), ALC-0315, and SM-102 are the only ionizable cationic lipids currently clinically approved for RNA therapies. ALC-0315 and SM-102 are structurally similar lipids used in SARS-CoV-2 mRNA vaccines, while MC3 is used in a …

D-Lin-MC3-DMA (MC3), (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate, is a ionizable lipid used for making Lipid Nano-Particles (LNPs). These lipids can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into cells.

Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo.

May 13, 2024 · Here we describe an accelerated approach to discovering effective ionizable lipids for mRNA delivery that combines machine learning with advanced combinatorial chemistry tools. Starting from a...

A. Lipid Mix Solution Preparation: The lipid mix solution consists of DLin- MC3-DMA (Cat. No. 7946), DSPC (Cat. No. 79 43), Cholesterol (Cat. No. 7945), and DMG-PEG 2000 (Cat. No. 7944) at the molar ratio of 50/10/38.5/1.5, which has been optimally formulated for LNP applications . 1. Transfer 150 μL of DLin-MC3-DMA into a tared glass vial.

Jul 13, 2023 · For MC3, different parameterizations in combination with the CHARMM and the Slipids force fields have recently emerged. Here, we complement the existing efforts by providing parameters for cationic and neutral MC3 compatible with the AMBER Lipid17 force field.

Feb 10, 2023 · DLin-MC3-DMA (MC3), currently the most potent cationic ionisable lipid in research, is widely used in the most popular formulation for lipid nanoparticles (LNPs) for mRNA delivery, along with cholesterol, the neutral helper lipid DSPC and the PEG lipid DMPE-PEG2000.