The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled …

Certain genetic changes in the MC1R gene modify the appearance of people with oculocutaneous albinism type 2. This form of albinism, which is caused by mutations in the OCA2 gene, is …

In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and exhibiting anti-inflammatory effects. First, …

May 31, 2016 · MC1R signaling promotes genomic stability through multiple mechanisms. MC1R activation induces translocation of NR4A2 to the nucleus in a p38 and PARP1 dependent …

The melanocortin 1 receptor (MC1R) gene encodes the receptor of melanocortin-stimulating hormone (also referred to as melanocyte-stimulating hormone or MSH), which is found on the …

Mar 30, 2025 · MC1R (Melanocortin 1 Receptor) is a Protein Coding gene. Diseases associated with MC1R include Skin/Hair/Eye Pigmentation, Variation In, 2 and Melanoma, Cutaneous …

Feb 1, 2022 · The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair …

The melanocortin‐1 receptor (MC1R) is a G protein‐coupled receptor that plays a pivotal role in human skin pigmentation, melanin synthesis, redox homeostasis and inflammation. …

MC1R polymorphisms reduce the ability of the melanocortin 1 receptor to stimulate eumelanin production, causing melanocytes to make mostly pheomelanin. Although MC1R is a key gene …

Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair …