Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]

Jul 25, 2023 · Major basic protein (MBP) is an eosinophil granule protein. Eosinophil granules contain a crystalloid core comprised of MBP and a matrix consisting of other toxic and pro-inflammatory mediators. MBP is the predominant constituent in eosinophil granules.

CSF myelin basic protein is a test to measure the level of myelin basic protein (MBP) in the cerebrospinal fluid (CSF). CSF is a clear liquid that surrounds the brain and spinal cord. MBP is found in the material that covers many of your nerves.

Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively charged and lacks distinct structure in solution and therefore its intracellular partners are still mostly enigmatic.

Myelin basic protein (MBP) was detected primarily in nerve fibres innervating Meissner corpuscles and was localized outside the corpuscle (arrows in a, d and e). However, nerve fibres expressing MBP were detected inside a subpopulation of ∼25% of the Meissner corpuscles.

Myelin Basic Protein - The concentration of MBP is often increased in patients with demyelinating diseases such as multiple sclerosis and may be increased in patients with head injury, CNS trauma, tumor, stroke, and viral encephalitis.

Myelin basic protein (MBP), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. A member of the 'intrinsically disordered' or conformationally adaptable protein family, …

Myelin Basic Protein (MBP) is a highly charged extrinsic membrane protein found in both central and peripheral nervous system myelin. It constitutes about 5% of peripheral nervous system myelin protein and plays a role in binding negatively …

Major basic protein-1 (MBP-1) is one of four toxic proteins stored within the secondary granules of eosinophils (reviewed in 110) Soragni and coworkers found that MBP-1 forms nanocrystals within these granules as a means of storing the protein at a high concentration.

MBP is a 169 amino acid peptide that comprises 30% of the protein of the myelin sheath. While MBP is a useful test in the diagnosis of active MS, some patients with this disorder will have normal limits, especially during remissions, and elevations may be seen in other disorders as well.