The mechanism of MBP translation derepression at the local contact site of axon and oligodendrocyte is mediated by integrin-dependent activation of Src-family kinase Fyn. Previously Fyn was found in immunocomplexes with MBP in oligodendrocytes [ 65 ].

Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]

Dec 9, 2022 · Parvalbumin-expressing (PV +) basket cells are fast-spiking inhibitory interneurons that exert critical control over local circuit activity and oscillations. PV + axons are often myelinated,...

When coupled with the observation that MBP promotes axon wrapping via actin filament disassembly, evidence that MBP is translated within nascent myelin sheaths in response to neuronal activity provides an intriguing model for the control of sheath formation.

Our study provides a molecular and structural framework for understanding how myelin maintains its cytoplasm to function as an active axon-glial unit. In the CNS, myelin is formed by oligodendrocytes that spirally wrap their plasma membrane around axons.

Apr 29, 2021 · In vivo, PCS-seeded murine NPCs stably overexpressing Mbp significantly enhanced locomotive recovery and axonal regeneration in post-SCI mice. We discovered that Mbp supports axonal regeneration from mammalian NPCs through the novel Mbp/L1cam/Pparγ signaling pathway.

Sep 27, 2013 · Mbp mRNA is transported from the nucleus to the plasma membrane and is translated locally at the axon–glial contact site. Axonal properties such as diameter or electrical activity influence the degree of myelination.

Apr 29, 2021 · We discovered that Mbp supports axonal regeneration from mammalian NPCs through the novel Mbp/L1cam/Pparγ signaling pathway. This study suggests that bioengineered, NPC-based interventions can promote axonal regeneration and functional recovery post-SCI.

Interestingly, the expression of myelin basic protein (MBP) facilitates axon wrapping as MBP binds to PI(4,5)P2 and induces the release of gelsolin and cofilin from the membrane (Fig. 4, ).

Jan 16, 2014 · MBP mRNA is transported to the growing tip of oligodendroglial processes (Ainger et al., 1993), and translation of MBP is induced at the innermost myelin layers that are in contact with the axon (Colman et al., 1982, Trapp et al., 1987, Wake et al., 2011, Laursen et al., 2011).