Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene. [5] [6] [7] MASP-1 is involved in the lectin pathway of the complement system and is responsible for activating MASP-2 and MASP-3. [8]

Dec 25, 2024 · MASP1 (MBL Associated Serine Protease 1) is a Protein Coding gene. Diseases associated with MASP1 include 3Mc Syndrome 1 and 3Mc Syndrome . Among its related pathways are Initial triggering of complement and Complement cascade .

The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by ...

novel 45-kDa serum protein derived from the MASP1 gene, which is highly expressed in striated muscle tissues and is found in complex with MBL and ficolins and may function as a potent inhibitor of the complement system in vivo

The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction.

Mannose-binding lectin (MBL) is a serum component which participates in innate immunity by activating complement via a novel pathway. Human MBL forms complexes with two types of serine proteases termed MASP (MBL-associated serine protease). These two proteases, MASP1 and MASP2, are structurally simi …

Dec 10, 2024 · The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of …

Sep 14, 2016 · The MASP1 gene provides instructions for making proteins that are involved in a series of steps called the lectin complement pathway. This pathway is thought to help direct the movement (migration) of cells during development before …

Wild-type (WT), mannose-binding lectin (MBL-A/-C) null, C2/factor B null (C2/fB null), and MBL-associated serine protease-1/-3 knock out (MASP1/3 KO) mice raised on a C57BL/6 background were used for the present study.

Jul 15, 2009 · Mannose-Binding Protein-Associated Serine Proteases / genetics Peptide Fragments / chemistry Protein Conformation