Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. [5] LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis.

Mar 30, 2025 · MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include Pancreatic Ductal Adenocarcinoma and Smith-Mccort Dysplasia 2. Among its related pathways are Early SARS-CoV-2 Infection Events and Selective autophagy.

Feb 16, 2025 · A missense mutation (Y113C) in the MAP1LC3B/LC3B (microtubule associated protein 1 light chain 3 beta) protein occurred at a significant frequency in cancer, and was detected in early stages in primary tumors of patients with known tumor lineage.

The microtubule-associated light chain 3B (MAP1LC3B) acts as an autophagy receptor for autophagosome elongation in mammalian cells [7]. High expression of MAP1LC3B is associated with poor survival [3] but also has better outcomes in patients with different types of cancer [8].

Feb 1, 2025 · Microtubule-associated protein 1 light chain 3B (MAP1LC3B, also known as LC3B) is a mammalian homolog of the autophagy-related protein 8 (ATG8) family. It plays a crucial role in cellular autophagy and is involved in several vital …

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by …

Jan 13, 2025 · Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1. This study suggests that autophagy could play a role in placental invasion system and …

Feb 19, 2024 · Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components.

Oct 8, 2018 · The LC3 family comprises of three highly homologous members, MAP1LC3A (LC3A), MAP1LC3B (LC3B), and MAP1LC3C (LC3C). The purpose of this study was to determine whether the LC3B isoform plays a specific role in maintaining RPE lipid homeostasis.

Autophagy is the bulk degradation of cellular proteins and organelles through lysosomes in eukaryotes and vacuoles in yeast. MAP1LC3B is 1 of 3 human orthologs of the yeast autophagosome protein Atg8 (Tanida et al., 2004).