Jul 21, 2021 · The m6A/m6Am writer enzymes are RNA methyltransferases (MTases). Structures are available for functionally characterized m6A RNA MTases from human (m6A mRNA, m6A …

Jun 29, 2015 · Here we developed m6A individual-nucleotide-resolution cross-linking and immunoprecipitation (miCLIP) and used it to demonstrate that antibodies to m6A can induce …

Aug 6, 2021 · Here, we report m 6 Am-seq, based on selective in vitro demethylation and RNA immunoprecipitation. m 6 Am-seq directly distinguishes m 6 Am and 5′-UTR N 6 …

Dec 21, 2016 · Here we show that this nucleotide, N6,2′- O -dimethyladenosine (m 6 A m), is a reversible modification that influences cellular mRNA fate. Using a transcriptome-wide map of …

We identify areas that remain to be investigated, propose yet unexplored routes for structural characterization of MTase:substrate complexes, and highlight common structural elements …

Jan 16, 2020 · Here, we report the m 6 A and m 6 Am methylome through profiling of 43 human and 16 mouse tissues and demonstrate strongest tissue specificity for the brain tissues. A …

Feb 2, 2023 · Here, we review RNA m6A modification in the light of the recent appreciation of nuclear roles for m6A in regulating chromatin states and gene expression, as well as the …

N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A …

Jan 16, 2020 · Here, we report the m 6 A and m 6Am methylome through profiling of 43 human and 16 mouse tissues and demonstrate strongest tissue specificity for the brain tissues. A …

Sep 20, 2018 · Wei et al. show that FTO mediates internal m6A and cap m6Am demethylation of polyadenylated RNA with differential substrate preferences in the nucleus versus the …