Genetic drivers of m6A methylation in human brain, lung, heart …
Jul 1, 2021 · Analysis of 129 N6-methyladenosine (m6A) profiles across 4 tissues (brain, lung, muscle and heart) identifies 8,843 tissue-specific and 469 tissue-shared m6A quantitative trait …
m6aVar-Database of functional variants involved in m6A …
We collected millions of variants from dbSNP and TCGA project, as well as thousands of m 6 A sites from 7 miCLIP experiments, 2 PA-m 6 A-Seq experiments and 244 MeRIP-Seq …
Genetic drivers of m6A methylation in human brain, lung, heart …
We integrate m 6 A QTLs with disease genetics, identifying 184 GWAS-colocalized m 6 A QTL, including brain m 6 A QTLs underlying neuroticism, depression, schizophrenia and anxiety; …
m6A epitranscriptomic regulation of tissue homeostasis during
Apr 6, 2023 · Our study provides a resource for elucidating m6A-mediated mechanisms of tissue aging and reveals a METTL3–m6A–NPNT axis counteracting aging-associated skeletal …
m6A RNA methylation regulates the fate of endogenous retroviruses …
Jan 13, 2021 · Here, using an unbiased genome-scale CRISPR knockout screen in mouse embryonic stem cells, we identify m6A RNA methylation as a way to restrict ERVs.
Exploring the prognostic potential of m6A methylation regulators …
Jan 3, 2024 · The biological behavior of low-grade glioma (LGG) is significantly affected by N6-methyladenosine (m6A) methylation, an essential epigenetic alteration. Therefore, it is crucial …
mRNA m6A regulates gene expression via H3K4me3 shift in 5’ …
Mar 12, 2025 · We demonstrate that m 6 A methylation in the 5’ UTR of mRNA triggers a downstream shift in H3K4me3 modification. This regulatory mechanism is conserved in …
A combined deep learning framework for mammalian m6A site …
Dec 11, 2024 · In this study, we developed an m6A site predictor called deepSRAMP, which integrates sequence-based and genome-derived features into the combination structure of a …
Roles of m6A modification in neurological diseases - PubMed
Jan 28, 2022 · N6-methyladenosine (m6A) methylation modification is one of the most common epigenetic modifications for eukaryotic mRNA. Under the catalytic regulation of relevant …
m6A Methylation in Cardiovascular Diseases: From Mechanisms to ...
In this review, we highlight advances in CVD-specific research concerning m6A modification, summarize the mechanisms underlying the involvement of m6A modification during the …