The mRNA m6A modification has been characterized biochemically, molecularly, and phenotypically, including elucidation of its methyltransferase complexes (m6A writer), …

Dec 16, 2019 · Here we show that N6 -methyladenosine (m 6 A) modification, contributing to different aspects of messenger RNA metabolism 5, 6, is detectable on the majority of …

M6A methylation is also widespread in bacteria, influencing functions such as DNA replication, repair, and gene expression, and prokaryotic defense. In replication, M6A modifications mark …

Feb 21, 2021 · We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future. Epigenetics is a discipline that modulates heritable gene expression …

Recent advancements in detection techniques have identified DNA N6-methyldeoxyadenosine (6mA) and RNA N6-methyladenosine (m6A) as methylation modifications at the sixth position …

Sep 7, 2022 · We show that RNA m 6 A guides DNA 5mC demethylation and thereby reprograms chromatin accessibility and gene transcription. Our results uncover a layer of epigenetic …

6 days ago · While m6A marks are known to exist in bacterial DNA, evidence of them in mammalian DNA has been a topic of debate. The findings of Conti et al. suggest that these …

Apr 25, 2024 · M6A regulates DNA repair through the R-loop to maintain genomic stability. DNA damage agents induce strand breaks to activate DNA damage response and ATM, thereby …

Apr 8, 2021 · Recent studies have shown that m 6 A can be induced by oxidative stress and DNA damage to regulate DNA repair. Also, deficiency of the m 6 A eraser, fat mass obesity …

Aug 6, 2019 · Our study identifies a novel layer of gene regulation for key ripening genes and establishes an essential molecular link between DNA methylation and mRNA m 6 A …