Our study provides a unifying molecular mechanism for high angiogenic capacity of TIMP-free proMMP-9 that would be uniquely produced in a pathophysiological microenvironment by influxing neutrophils and/or M2 polarized macrophages.

In the present study, we hypothesized that MGCs express endogenous MMP-9 and TIMP-1, the expression of which is altered in retinal remodeling during retinal degeneration. We investigated how these proteins are expressed in human MGCs under normal, inflammatory, and oxidative stress conditions.

MMP-9 is most dominantly MMP present in atherosclerotic plaques and is produced by M2 rather than M1 macrophages. Key words: Matrix metalloproteinase, Macrophage, Atherosclerotic plaque, Smooth muscle cell, MMPSense.

Dec 15, 2009 · Matrix metalloproteinase (MMP)-9 (gelatinase B) participates in a variety of diverse physiologic and pathologic processes. We recently characterized a cyclooxygenase-2 (COX-2)-->PGE (2)-->EP4 receptor axis that regulates macrophage MMP-9 expression.

May 15, 2020 · MMP-9 is one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to degrade the extracellular matrix (ECM) components and has important role in the pathophysiological functions. Overexpression and dysregulation of MMP-9 is associated with various diseases.

Dec 17, 2018 · Within proteins that are differentially expressed in M1- and M2-like TAM subtypes, we were particularly interested in MMP-9, a member of MMP family, because it has been shown to play a role in extracellular matrix remodeling and invasion in breast cancer.

May 2, 2024 · Our data suggest that MMP-9 is a druggable node linking inflammation to HO, orchestrates an existential role in the pathogenesis of FOP, and illustrates that a single patient's clinical phenotype can reveal critical molecular mechanisms of disease that …

Jul 16, 2021 · In the present study, MMP-9 and TIMP-1 expression patterns were investigated in a human MGC line (MIO-M1) under inflammatory cytokine (IL-1β and TNF-α) and oxidative stress (H 2 O 2) conditions. First, both IL-1β and TNF-α, but not H 2 O 2, have a mild in vitro pro-survival effect on MIO-M1 cells.

Profibrotic VICs downregulate MMP-9 and stimulate IL1-band COL6A1 production on in flam-matory M1-macrophages, sug-gesting a key role of macrophages/VIC crosstalk at early stages of AVS development. This study highlights that the interactions be-tween pro fibrotic VIC and in flammatory macro-phages are bidirectional.

Jan 11, 2021 · Matrix metalloproteinase-9 (MMP-9) is expressed in the macrophage, and has a pivotal role in secreting inflammatory cytokines. We reported that saquinavir (SQV), a first-generation human...