MMP-3 can activate multiple pro-MMPs and thus initiates the MMP-mediated degradation reactions. In this review, we summarized the function of MMP-3 and discussed its effects on biological activities.

Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [5] MMP-3 has an estimated molecular weight of 54 kDa. [6]

These data indicate a dual role for MMPs in biphasic modulation of inflammatory-mediator activity: they are involved in both activation (MMP3 and MMP9, and more weakly MMP2) and inactivation...

A potential mechanism of MMP3 in regulating tumor cell proliferation and invasion was mediated via Erk1/2 an NF-κB signaling. This study reveals that MMP3 is a promising target and the combined treatment with oncolytic virus is a potential strategy for cancer therapy. Introduction

Oct 29, 2010 · MMP-3 activity is regulated at three different levels: gene expression, proteolytic activation of the zymogen, and inhibition by the endogenous tissue inhibitors of metalloproteinase. A line of evidence indicates a role of MMP-3 in neurodegeneration.

Nov 25, 2011 · Mitogen-activated protein (MAP) kinase pathways regulate cell growth, differentiation, gene expression, protein synthesis and secretion. Three MAP kinase pathways have been studied in detail: extracellular signal-regulated kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38 pathways.

In vitro, cultured lung epithelial cells exposed to purified MMP3 upregulated β-catenin signaling pathways, with resultant epithelial-to-mesenchymal transition. 66 MMP3 also cleaves and activates osteopontin. 61. Several other MMPs have been implicated in the pathogenesis of IPF.

Angiotensin II (AngII) is a central signaling molecule of the renin-angiotensin system that serves a vital role in myocardial fibrosis (MF). The present study aimed to investigate the effects of matrix metalloproteinase (MMP)3 on MF progression. To induce cellular fibrosis, H9C2 rat myocardial cells were treated with AngII for 24 h.

Sep 5, 2013 · Here, we identify matrix metalloproteinase-3 (MMP3) as a regulator of Wnt signaling and mammary stem cell (MaSC) activity. We show that MMP3 overexpression promotes hyperplastic epithelial growth, surprisingly, in a nonproteolytic manner via its …

Jul 1, 2021 · MMP-3 can activate multiple pro-MMPs and thus initiates the MMP-mediated degradation reactions. In this review, we summarized the function of MMP-3 and discussed its effects on biological activities.