These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

For mature macrophage populations, about 90–100% alveolar macrophages and peritoneal macrophages were LysM +, whereas only 40% of spleen red pulp or spleen marginal zone …

In 1999, a myeloid-specific Cre-expressing mouse line, LysM-Cre, was generated by Förster and colleagues through directly inserting engineered Cre cDNA into the endogenous lysozyme 2 …

To test the contribution of LysM in sterile acute lung injury, we generated LysM-Cre mice homozygous for the Cre allele (+/+) or wild-type allele (−/−). These mice were challenged with …

Nov 8, 2019 · These findings indicate that loss of LysM and expression of Cre recombinase are non-contributory in sterile acute lung injury. Lysozyme is an important component of the innate …

Mar 18, 2025 · View Lyz2<tm1(cre)Ifo> allele: origin, molecular description and human disease models, images, gene associations, and references.

Apr 4, 2025 · The Cre-Lox system is a powerful tool in mouse genetics, enabling precise spatiotemporal control of gene expression and conditional knockout models. ... Long et al. …

These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

In order to delete loxP-site flanked genes in myeloid cells, a Cre-recombinase (Cre) expressing mouse line was created by inserting Cre-coding sequence into the translational start site of the …

Aug 25, 2022 · In 1999, a myeloid-specific Cre-expressing mouse line, LysM-Cre, was generated by Förster and colleagues through directly inserting engineered Cre cDNA into the …