Hou et al. show that cardiac fibroblasts facilitate infiltrating Ly6Chi and Ly6Clo monocytes to become macrophages. IL-17A trans-signaling through cardiac fibroblasts increases MerTK …

To test the overall contribution of the Cd36-Mertk axis, MI was induced in Cd36 −/− Mertk −/− double-knockout mice and led to increases in myocardial rupture. These data implicate …

Infarction triggers the early recruitment of Ly6CHI monocytes, which transition into resolving Ly6CLO macrophages. Previous studies have linked key apoptotic cell receptors, such as …

Sep 13, 2021 · Transplantation of BM-MSCs markedly promoted a phenotypic switch from pro-fibrotic Ly6Chi subset to restorative Ly6Clo subpopulation by secreting paracrine cytokines IL …

Here, we show that infiltrating Ly6C hi monocytes, their macrophage descendants, and neutrophils spatially and temporally overlap in the centrilobular necrotic areas during the …

Jan 22, 2014 · The role of MerTK in shaping the monocyte/macrophage response after PVA sponge implantation was investigated using mice that are deficient in MerTK signaling (MerTK …

The scavenger receptor cluster of differentiation (CD)36 protein was detected on cardiac Ly6cHI monocytes, and bone marrow-derived Cd36 was essential for both early phagocytosis of dying …

To define macrophages we took advantage of recent findings that co-expression of the tyrosine kinase Mer (MerTK) and CD64 provides a robust marker for macrophages in the liver . F4/80 …

Sep 13, 2021 · The activation of the MerTK-ERK pathway was accompanied with the secretion of MMP12. The correlation among MerTK, ERK1/2, and MMP12 was evidenced by utilizing a …

Nov 15, 2024 · In this study, we examined surface integrins' role in TAM recruitment and phenotypic programming in a 4T1-induced murine breast tumor model. Our findings show that …