Jan 4, 2021 · Recently, the emerging role of the oncoprotein B cell lymphoma 6 (BCL6) in tumorigenesis and stress response has been unveiled. Here, we demonstrate that BCL6 was upregulated upon BET inhibition in KRAS-mutant cancers, including non …

Nov 11, 2022 · Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS -driven lung cancer. BCL6 expression was increased upon KRAS activation in lung tumor tissue in mice and was positively correlated with the expression of KRAS-GTP, the active form of KRAS, in various human cancer cell lines.

BCL6 deficient mice die within a few weeks of birth and exhibit massive tissue infiltration of inflammatory cells in lung, heart and other tissues (2 – 4). Loss of BCL6 in macrophages causes accelerated atherosclerosis in mice (22).

Feb 29, 2024 · BCL6 inhibits NLRP3-mediated inflammation, attenuates alveolar simplification and dysregulated pulmonary vessel development in hyperoxia-induced BPD mice. Hence, BCL6 may be a target in treating BPD and neonatal diseases.

Nov 15, 2022 · Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS-driven lung cancer. BCL6 expression was increased upon KRAS activation in lung tumor tissue in mice and was positively correlated with the expression of KRAS-GTP, the active form of KRAS, in various human cancer cell lines.

Jun 1, 2017 · A bioinformatics search identified BCL6, a gene downstream of SMAD2/3, as a novel pharmacologically accessible target of our transformed HBECs. Combination treatment …

We find that the loss of BCL6 in neutrophils mitigates lung inflammation and promotes host resistance to IAV infection. The data provide mechanistic insight into how BCL6 regulates neutrophil-mediated lung inflammation through modulating neutrophil apoptosis at …

Nov 15, 2022 · Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS-driven lung cancer. BCL6 expression was increased upon KRAS activation in lung tumor tissue in mice and was positively correlated with the expression of KRAS-GTP, the active form of KRAS, in various human cancer cell lines.

Jan 1, 2021 · Recently, the emerging role of the oncoprotein B cell lymphoma 6 (BCL6) in tumorigenesis and stress response has been unveiled. Here, we demonstrate that BCL6 was upregulated upon BET inhibition in KRAS -mutant cancers, …

Jan 4, 2021 · Recently, the emerging role of the oncoprotein B cell lymphoma 6 (BCL6) in tumorigenesis and stress response has been unveiled. Here, we demonstrate that BCL6 was upregulated upon BET inhibition in KRAS-mutant cancers, including non–small-cell …