The lowest mean CD7 counts (as a percentage of total lymphocytes) were found in MF (patch stage: 5% +/- 5%, range: 0-10; plaque and tumor stages: 15% +/- 5%, range: 5-25), and these counts were significantly lower than those for BID (35% +/- 20%, range: 5-80; p = 0.001).

CD7 is a transmembrane protein highly expressed in acute T-cell leukemia (T-ALL) and in a subset of peripheral T-cell lymphomas. Normal expression of CD7 is largely confined to T cells and natural killer (NK) cells, reducing the risk of off-target-organ toxicity.

CD7, also known as GP40, is a membrane-expressed protein that belongs to the immunoglobulin superfamily. CD7 expression was detected in T cells and subsequently shown to also be present on natural killer (NK) cells [, , ], indicating a role for CD7 in the immune system.

Targeting T cell malignancies with universal CD7-targeting chimeric antigen receptor T cells (UCART7) can lead to profound immune deficiency due to loss of normal T and NK cells.

Mar 1, 2003 · CD7 identifies three populations of CD8 T cells: CD7 high (CD7(high)), low (CD7(low)), and negative (CD7(neg)) that translate into subsets with distinct functional properties. The CD7(high) subset contains naive and memory cells and the CD7(low) and CD7(neg) subsets contain effector cells.

Nov 21, 2017 · Blockade of CD7 expression with a novel method, combined with a second-generation CAR, results in highly potent anti-CD7 CAR T cells. This practical strategy provides a new treatment option for patients with high-risk T-cell malignancies, including ETP-ALL. Effective immunotherapies for T-cell malignancies are lacking.

Nov 16, 2007 · We observed frequent CD7 antigen loss in our series of Korean patients with ANKL. This characteristic immunophenotypic finding can provide a reliable and timely information as a diagnostic marker in ANKL along with cytogenetic findings.

Dec 22, 2022 · CD7 is an attractive antigen for targeting T-ALL, but overlapping expression on healthy T cells leads to fratricide of CD7-CAR T cells, requiring additional genetic modification. We took advantage of naturally occurring CD7 − T cells to …

Mar 1, 2003 · CD7 identifies three populations of CD8 T cells: CD7 high (CD7 high), low (CD7 low), and negative (CD7 neg) that translate into subsets with distinct functional properties. The CD7 high subset contains naive and memory cells and the …

Jun 19, 2024 · In autoimmune diseases, modulating CD7 activity could help restore immune tolerance and reduce inflammation. Researchers are investigating the potential of CD7 inhibitors or modulators to treat conditions such as rheumatoid arthritis, multiple sclerosis, and psoriasis.