Graft versus host disease (GVHD) is a common complication following allogeneic hematopoietic cell transplantation (HCT) that typically manifests as injury to the skin, gastrointestinal mucosa, and liver. In some cases, hepatic GVHD may be ...

Aug 27, 2024 · (See "Pathogenesis of graft-versus-host disease (GVHD)".) Clinical manifestations of acute GVHD include a classic maculopapular rash; persistent nausea and/or emesis; abdominal cramps with diarrhea; and a rising serum bilirubin concentration.

GVHD is an immune-mediated complication that can develop in up to 70% of hematopoietic stem cell transplant (HCT) recipients and rarely in solid organ recipients and other immunosuppressed conditions.

GVHD develops due to T lymphocytes present in the graft attacking the host antigens, which results in tissue damage. A significant number of HCT patients develop acute or chronic GVHD, which may affect multiple organs including the liver.

Nov 1, 2023 · Liver biopsy is not only important for diagnosis but also for assessing hGVHD activity, degree of duct loss, and degree of fibrosis; there is emerging evidence that it can also be used for prognostication [20, 21, 66].

Liver Graft-versus-host disease (GVHD) is common in patients with post-transplant liver dysfunction following allogeneic hematopoietic stem cell transplantation (AHSCT). Oftentimes, the diagnosis is made clinically, and liver biopsy is deferred. Our ...

Aims: To analyse the histological features of 33 patients (48 biopsy specimens) with a clinicopathological diagnosis of graft vs. host disease of the liver (L-GVHD). Results: The time of biopsy post-haematopoietic stem cell transplantation (HSCT) ranged from 22 to 1082 days (median 144 days).

Oct 21, 2005 · If no other signs of GVHD are present, a liver biopsy may be necessary. Although HCV causes inflammation and reactive bile duct changes [6,13,22], the withered degenerative bile duct changes of GVHD are qualitatively different from those caused by HCV (Figure 1 A and B).

Moderate degree of bile duct injury and intraepithelial lymphocytes were the most helpful histologic findings to confirm the diagnosis of GVHD. In addition, it is important for the pathologist to be aware of the etiologies of liver dysfunction other than GVHD.

Mar 24, 2016 · Treatment of acute graft-versus-host disease (GVHD) has evolved from a one-size-fits-all approach to a more nuanced strategy based on predicted outcomes. Lower and time-limited doses of immune suppression for patients predicted to …