The word liposome derives from two Greek words: lipo ("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid. [citation needed]Liposomes were first described by British hematologist Alec Douglas Bangham [10] [11] [12] in 1961 at the Babraham Institute, in Cambridge—findings that were published 1964. The discovery came about when Bangham and R. W. Horne ...

Liposomes; Phospholipids; Lamellarity; Stealth liposomes; Vaccinations. 1. Introduction. Drug delivery systems (DDSs) offer the potential to enhance the therapeutic index of drugs by increasing the drug concentration, the residence time in target cells and minimizing the side effects [].DDSs involve delivering the potentially active drug to the site of action via a nano-vehicle to enhance the ...

Abstract. Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were first described in the mid-60s. Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and biology.

3. Structures and Main Components of Liposomes 3.1. Structures of Liposomes. Liposomes can be classified as unilamellar vesicles (ULVs), oligolamellar vesicles (OLVs), multilamellarvesicles (MLVs), and multivesicular liposomes (MVLs) depending on the compartment structure and lamellarity [].OLVs and MLVs show anonion-like structure but present 2–5 and >5 concentric lipid bilayers, respectively.

Feb 26, 2018 · Liposome Definition. A liposome is a closed, spherical lipid bilayer, which forms an internal cavity capable of carrying aqueous solutions.A lipid bilayer is composed of two sheets of tightly arranged phospholipids.These molecules have a hydrophobic tail and a hydrophilic head region. When two single membranes come together, the hydrophobic tails attract toward each other, while the heads of ...

May 13, 2022 · Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes also proved to enhance drug solubility and controlled distribution, as well as …

Sep 9, 2021 · Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including …

Jan 29, 2019 · A liposome is a spherical-shaped vesicle that is composed of one or more phospholipid bilayers, which closely resembles the structure of cell membranes. The ability of liposomes to encapsulate ...

A liposome is a lipid bilayer composed of phosphatidylcholine-enriched phospholipids. Liposome may also contain lipid or lipid chains such as cholesterol, sphingolipids, long-chain fatty acids, and phosphatidylethanolamine (van Meer et al., 2008).Liposome is a small vesicle of spherical shape with an internal aqueous environment and hydrophobic membrane layer …

Chemical structures of DOTMA, DOTAP, and DDAB. 2.2. Cholesterol. Cholesterol plays an important role in cell membranes and acts as the precursor to the biosynthesis of several compounds, including bile acid, Vitamin D, and steroid hormones [27,28,29].Structurally, cholesterol is a rigid molecule with a steroid skeleton of four fused rings, three six-member rings, and one five-member ring ().