Jun 21, 2016 · Established transfection methodology often uses commercial reagents, which must be formed into liposomes in a sequence of about half a dozen steps. The simplified method …

Feb 1, 2022 · Liposome complexation is a method of modifying the structure of a liposome to improve its physicochemical properties, stability, and pharmacokinetic profile. Liposomes that …

Jun 19, 2012 · Among nonviral vectors, cationic liposomes are the most promising candidates for gene delivery. They form stable complexes with polyanionic DNA (lipoplexes). Despite several …

In this study, the ratio of the lipoplex constituents, acidic and alkaline complexation solution, and lipoplex formation and decomplexation were investigated to improve the transfection efficiency …

Plasmid DNA can be enveloped with lipids in an organized structure, such as a micelle or a liposome conjugated with DNA, called a lipoplex. Three types of lipids can be used for …

Jun 7, 2024 · Comprising lipid-based formulations intricately intertwined with nucleic acids, lipoplexes offer a versatile platform for targeted delivery of therapeutic payloads, including …

The increasing number of entry of lipoplex-based gene therapy in the clinical trials shows the potential of lipoplex as a well-characterized system with consistent quality and reliable …

Nov 20, 2014 · A liposome-coated lipoplex (L-cL) consists of a core arising from complexation of positively charged lipid and negatively charged oligodeoxynucleotide (ODN) or plasmid DNA …

Mar 19, 2015 · Here we compared the biological and biophysical properties of a lipopolyplex formulation with its lipoplex and polyplex equivalents to assess the role of the lipid and peptide …

Liposome complexation is a method of modifying the structure of a liposome to improve its physicochemical properties, stability, and pharmacokinetic profile. Liposomes that have been …