A Conserved Noncoding Locus Regulates Random Monoallelic
Jan 16, 2020 · Unlike Tsix, LinxP is well conserved across mammals, suggesting an ancestral mechanism for random monoallelic Xist regulation. When introduced in the same TAD as Xist, …
The Molecular and Nuclear Dynamics of X-Chromosome Inactivation
The recent discovery that LinxP (the promoter of the Linx noncoding RNA), which lies in the Tsix -TAD, acts as a long-range silencer of Xist across the Xist / Tsix -TADs boundary (Fig. 3 A2), …
A Conserved Noncoding Locus Regulates Random Monoallelic Xist ...
LinxP’s repressive action occurs at a distance of u0001170 kb and across a TAD boundary. Consistent with this action on Xist, LinxP binds two known repressors of Xist, the pluripotency …
High-resolution Xist binding maps reveal two-step spreading …
Dec 19, 2013 · Here we generate high-resolution maps of Xist binding on the X chromosome across a developmental time course using CHART-seq. In female cells undergoing XCI de …
A long noncoding RNA influences the choice of the X chromosome ... - PNAS
Recently it was reported that the promoter region of the noncoding RNA Linx (LinxP) acts as a cis-regulatory element and long-range silencer to influence the choice of X chromosome to be …
Dynamic interplay and function of multiple noncoding genes …
The X inactivation center (Xic is essential for induction of X chromosome inactivation and harbors two topologically associated domains (TADs) to regulate monoallelic Xist expression: one at …
Tsix, a gene antisense to Xist at the X-inactivation centre - Nature ...
Apr 1, 1999 · We found evidence for an RNA antisense to Xist when examining Xist expression in embryonic stem (ES) cells using strand-specific probes by RNA fluorescence in situ …
Review Origin and evolution of the long non-coding genes in the …
Nov 1, 2011 · Random X chromosome inactivation (XCI), the eutherian mechanism of X-linked gene dosage compensation, is controlled by a cis -acting locus termed the X-inactivation …
A Conserved Noncoding Locus Regulates Random Monoallelic
Nov 20, 2019 · Unlike Tsix, LinxP is well conserved across mammals, suggesting an ancestral mechanism for random monoallelic Xist regulation. When introduced in the same TAD as Xist, …
Unlike Tsix, LinxP is well conserved across mammals, suggesting an ancestral mechanism for random monoallelic Xist regulation. When introduced in the same TAD as Xist, LinxP switches …