Concomitant Activation of OSM and LIF Receptor by a Dual
Dec 29, 2021 · In mice, oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) are selectively activated by the respective cognate ligands while OSM activates both …
The clinical relevance of OSM in inflammatory diseases: a …
As a member of the interleukin-6 (IL-6) family of cytokines, OSM binds the shared receptor gp130, recruits either OSMRβ or LIFRβ, and activates a variety of signaling pathways including the …
A unique loop structure in oncostatin M determines binding …
Sep 21, 2012 · In this study, we show that the BC loop does not play a role in OSM's unique ability to bind OSMR. Shortening of the loop enhanced OSM's interaction with OSMR and …
Pharmacological inhibition of the LIF/LIFR autocrine loop reveals ...
May 24, 2024 · Analysis of cancer databases revealed that elevated expression of LIF or LIFR was associated with poor progression-free survival of OCa patients and a predictor of poor …
A Unique Loop Structure in Oncostatin M Determines Binding …
OSM is unique in this family as it can signal using heterodimers of gp130 with either leukemia inhibitory factor receptor (LIFR) (type I) or oncostatin M receptor (OSMR) (type II). We have …
Cross-reactivity of two human IL-6 family cytokines OSM and LIF ...
Jul 1, 2021 · Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are two important pro-inflammatory cytokines of the interleukin-6 (IL-6) family.
Oncostatin M: Dual Regulator of the Skeletal and Hematopoietic …
Oncostatin M (OSM) is an inflammatory cytokine of the interleukin-6 family produced by osteoblasts, bone marrow macrophages, and neutrophils. OSM acts via two heterodimeric …
Exploring the oncostatin M (OSM) feed-forward signaling of glioblastoma ...
Oct 26, 2021 · OSM-mediated downstream signal transduction depends on two specific heterodimers on the cell surface: gp130/OSM receptor (OSMR) and gp130/leukemia inhibitory …
Cross-reactivity of two human IL-6 family cytokines OSM and LIF ...
Jul 1, 2021 · Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are two important pro-inflammatory cytokines of the interleukin-6 (IL-6) family.
Dual Oncostatin M (OSM) Receptors - Journal of Biological Chemistry
The BAF-gp130/LIFR cell line (expressing LIF/OSM or type I OSM receptors) is capable of proliferation after stimulation with either LIF or OSM. BAF-gp130/OSMRβ cells demonstrate a …