Results: LiCl stimulated Wnt activation and expression of Wnt markers in C2C12 cells on modSLA. Addition of 1 mM LiCl increased levels for bone marker Osteocalcin in MC3T3 cells on modSLA surfaces. Similarly, LiCl potently enhanced Osteoprotegetrin levels in …

We used polymerase chain reaction and Western blotting to establish the effect of GSK-3 β inhibition on the nuclear factor- κ B (NF- κ B) pathway. Results showed administration of LiCl increased apoptosis and the level of ROS in colorectal cancer cells.

The present study tested the hypothesis that in vitro treatment of skeletal muscle with lithium chloride (LiCl), a glycogen synthase kinase (GSK)-3 inhibitor, would reverse both the sepsis-induced increase in muscle protein degradation and inhibition of protein synthesis.

Apr 23, 2020 · Lithium chloride (LiCl) is a widely used drug for the treatment of bipolar disorders, but as a side effect, 40% of the patients develop diabetes insipidus. LiCl affects the activity of the glycogen synthase kinase 3 (GSK3), and mice deficient for GSK3β showed a reduction in the urine concentration capability.

Indeed, in early studies, it was discovered that millimolar concentrations of lithium chloride (LiCl) can specifically inhibit GSK-3β and can also activate the canonical Wnt signaling pathway (Klein and Melton, 1996; Stambolic et al., 1996).

购买Abcam Lithium chloride，GSK3beta抑制剂(CAS 7447-41-8) (ab120853)，纯度> 99%，分子式LiCl，GSK3β抑制剂。4篇文献引用，

Apr 23, 2020 · LiCl affects the activity of the glycogen synthase kinase 3 (GSK3), and mice deficient for GSK3β showed a reduction in the urine concentration capability. The cellular and molecular mechanisms are not fully understood.

Application of lithium chloride, a GSK-3β inhibitor, could efficiently attenuate the thapsigargin-induced tau hyperphosphorylation with suppressed activation of GSK-3β in cell cultures and rat brains.

Valproic acid (VPA) inhibits GSK3β by direct interaction. LiCl and VPA show additive effects on GSK3β inhibition. Like a pharmacological GSK3β inhibitor AR-A014418, olanzapine can be successfully...

Jun 20, 2006 · To assess whether GSK-3β affects the proliferation of ovarian cancer cells, we examined the effect of LiCl, a known inhibitor of GSK-3, on the growth of two human ovarian tumor cell lines, SKOV3...