Apr 24, 2024 · Our study revealed that the >10 KDa group was the main material basis of the leech extract that inhibited pulmonary fibrosis through TGF-β1/Smad3 signaling pathway.

Mar 1, 2024 · Leech extract was discovered in the late 19th century and since then many pharmaceutical products have been produced using leech extract for different ailments, but …

Jan 10, 2021 · Leech extract treatment under a hypertensive condition exerted significant cardio-protective benefits by reducing the expression of cardiac hypertrophy-related transcription …

Jan 10, 2021 · In this study, we aimed to delineate the molecular mechanisms of medicinal leech extract in the treatment of cardiac hypertrophy and fibrosis, using both in vitro and in vivo …

Medicinal leech therapy (MLT) or hirudotherapy, an old technique, has been studied by many researchers for possible effects on various diseases such as inflammatory diseases, …

They outlined that leech extract could be used in the treatment of bacteria-induced illnesses including arthritis, foodborne disorders, and nosocomial infections. They also highlighted a …

Dec 13, 2024 · Leech saliva contains versatile peptides and molecules that can exert anti-microbial, anti-inflammatory, anti-coagulant, and analgesic activities on the patients.

Apr 24, 2024 · Our study revealed that the >10 KDa group was the material basis of the extract of leech in treatment of pulmonary fibrosis, which can not only inhibit TGF-β1-induced lung …

The purpose of this review was to discuss the development of leech extract as a therapeutic agent, including the evolution of extraction techniques, and the successful manufacturing of …

Our preliminary studies have demonstrated that the leech extract group with molecular weight greater than 10 kDa (>10 kDa group) exhibited superior anti-idiopathic pulmonary fibrosis …