The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, [1] in that, after activation, it proceeds through the action of C4 and C2 to produce activated …

Sep 5, 2022 · The lectin pathway of the complement system in the innate immune system includes a cascade of enzymatic reactions in which carbohydrate-binding proteins called lectins initiate the reaction after binding to the surface of a wide range of pathogens.

The lectin pathway is perhaps the most complex activation pathway among the complement pathways; it has at least six PRMs, three serine proteases, and two non-catalytic fragments.

Aug 31, 2023 · The lectin pathway is activated by the interaction of microbial carbohydrates (lectins) with mannose-binding lectin (MBL) or ficolins found in the plasma and tissue fluids. The alternative complement pathway is activated by C3b binding to …

May 1, 2002 · The lectin pathway involves carbohydrate recognition by pattern-recognition receptors, such as mannose-binding lectin and ficolins, and the subsequent activation of associated unique enzymes...

Mar 18, 2025 · The lectin complement pathway is a key part of the immune system, providing an early defense against microbial invaders. Unlike the classical pathway, which depends on antibodies, it is activated by pattern recognition molecules that …

Jan 18, 2017 · Our aim was to describe the concentrations of the 11 known proteins of the lectin pathway in serum and plasma and to uncover possible gender differences, age and diurnal variations, which must be taken into account for investigation in different cohorts.

Activation of complement via the lectin pathway is initiated by several pattern-recognition molecules (PRM), complexed with mannose-binding lectin-associated serine proteases (MASP).

Oct 26, 2016 · Mannose-binding lectin (MBL), collectin-10, collectin-11, and the ficolins (ficolin-1, ficolin-2, and ficolin-3) are soluble pattern recognition molecules in the lectin complement pathway. These proteins act as mediators of host defense and participate in maintenance of tissue homeostasis.

The complement system is an effector mechanism in immunity. It is activated in three ways, the classical, alternative and lectin pathways. The lectin pathway is initiated by the binding of mannose-binding lectin (MBL) or ficolins to carbohydrates on the surfaces of pathogens.