Sep 20, 2022 · We uncover a non-canonical pathway implicating LDTg GABAergic projection to the ventral tegmental area (VTA), which subsequently impact amygdalar neurons to regulate unconditioned freezing...

Apr 4, 2022 · Here, we report a partial map of the engram complex for contextual fear conditioning memory by characterizing encoding activated neuronal ensembles in 247 regions using tissue phenotyping in mice.

May 14, 2021 · ErbB4 activation required the expression of NRG1 in the laterodorsal tegmentum (LDTg); LDTg-specific deletion of NRG1 inhibited depression-like behaviors. NRG1 and ErbB4 suppressed potassium...

The laterodorsal tegmental nucleus (LDTg) expresses GLP-1Rs and functions as a neuroanatomical hub connecting the nucleus tractus solitarius (NTS), the primary source of central GLP-1, with midbrain and forebrain nuclei known to regulate cocaine-seeking behavior.

Recent studies of the LHb have focused on its projections to the ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg), which contain GABAergic neurons that mediate reward prediction error via inhibition of dopaminergic activity.

By selectively inhibiting LDTg projections of various natures and to different targets, we unravelled a new GABAergic LDTg-VTA pathway that bidirectionally modulates freezing in response to acute stress.

CNO-induced activation of LDTg neurons projecting to the VTA combined with SubSD produced hyperactivity of VTA DA neurons. This effect was fully prevented by mecamylamine.

We demonstrated here, that NMU into the NAc shell, but not aVTA or LDTg, blocked the ability of acute alcohol to cause locomotor stimulation and to induce memory retrieval of alcohol reward, as well as reduced peanut butter in mice. In addition, NMU into …

Sep 20, 2022 · Here, we show that freezing elicited by exposure to electrical foot shocks activates laterodorsal tegmentum (LDTg) GABAergic neurons projecting to the VTA, without altering the excitability of cholinergic and glutamatergic LDTg neurons.

Jul 22, 2022 · These authors described robust cortical inputs to LDTg mostly emerging from VO, PrL, and cingulate cortices, further specifying that cortical regions preferentially target glutamatergic LDTg neurons expressing the vesicular glutamate receptor type 2 (VGLUT2).