The Lck is a member of Src kinase family (SKF) and is important for the activation of T-cell receptor (TCR) signaling in both naive T cells and effector T cells. The role of Lck is less prominent in the activation or in the maintenance of memory CD8 T …

Jan 3, 2023 · Interactions between the T cell co-receptors CD4 or CD8 and the kinase Lck safeguard T cell activation by low-affinity ligands. Meanwhile, ‘free’ Lck — which cannot bind co-receptors —...

The src family kinases p56lck (Lck) and p59fyn (Fyn) are the most proximal signaling molecules to be activated downstream of the T-cell receptor. Using an inducible transgenic model, we can regulate the expression of Lck in primary T cells and ask ...

Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of TCR signaling, T-cell development, and T-cell homeostasis. Because of the crucial role of Lck in T-cell responses, strategies have been employed to redirect Lck activity to improve the efficacy of chimeric antigen receptors (CARs) and ...

In the current work, transgenic mice bearing a 2.6-kb fragment of the human distal promoter fused to the SV40 large T antigen gene express large T antigen in thymocytes and in peripheral lymphoid cells, and develop tumors of both the thymus and the peripheral lymphoid organs.

Feb 21, 2025 · In mice expressing mutated endogenous LCK unable to bind co-receptors (LCK FREE mice), we show that influenza A virus (IAV)–derived pMHC-specific CD8 and CD4 T cell responses had a significantly narrowed T cell receptor …

Jan 8, 2021 · A new study now demonstrates that LCK can sense intracellular asparagine to support T cell receptor-mediated CD8 + T cell activation and effector responses to pathogens and tumours.

Dec 23, 2022 · Overall, our findings reveal the role of co-receptor-bound LCK in T cell biology, show that CD4- and CD8-bound LCK drive T cell development and effector immune responses using qualitatively...

Jun 6, 2010 · Here we showed that catalytically active Lck was present in unstimulated naive T cells and thymocytes and was readily detectable in these cells in lymphoid organs. In naive T cells up to ∼40% of total Lck was constitutively activated, part of which was also phosphorylated on the C-terminal inhibitory site.

Feb 4, 2020 · Horkova et al. reveal dynamic regulation of the coreceptor-LCK interaction during T cell development, establishing the self-reactivity of mature T cells. Differences between CD8 and CD4 coreceptors cause peripheral CD8+ T cells to be more self-reactive than CD4+ T cells.