LAT-Independent Erk Activation via Bam32-PLC-γ1-Pak1 …
Oct 26, 2012 · In T cells, the adaptor Bam32 is coupled to Erk activation downstream of the TCR by an unknown mechanism. We characterized in Jurkat cells and primary T lymphocytes a …
LAT-Independent Erk Activation via Bam32-PLC-γ1-Pak1
Oct 26, 2012 · In T cells, the adaptor Bam32 is coupled to Erk activation downstream of the TCR by an unknown mechanism. We characterized in Jurkat cells and primary T lymphocytes a …
Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is ...
Sep 15, 2000 · Linker for T-cell activation (LAT) is a recently identified 36- to 38-kd membrane adapter protein expressed in T cells, natural killer (NK) cells, mast cells, and megakaryocytes, …
Restoration of LAT activity improves CAR T cell sensitivity and ...
Mar 10, 2025 · Pham-Danis et al. demonstrate that antigen-low leukemias elicit insufficient LAT activation in second-generation CAR T cells. They develop a rationally designed adjunctive …
T Cell Receptor-Independent Basal Signaling via Erk and Abl
Nov 17, 2003 · Using DNA microarrays and Northern blots to analyze unstimulated cells, we demonstrate that expression of a cluster of genes, including RAG-1 and RAG-2, is repressed …
Lck promotes Zap70-dependent LAT phosphorylation by bridging …
Jun 18, 2018 · We report the discovery of a conserved proline-rich motif in LAT that mediates efficient LAT phosphorylation. Lck associates with this motif via its SH3 domain, and with …
Positive feedback between the T cell kinase Zap70 and its substrate LAT …
Jun 22, 2021 · We find that fibroblasts expressing synthetic Zap70:LAT clusters activate downstream signaling, whereas one-to-one heterodimers do not. We provide evidence that …
LAT Polices T Cell Activation - ScienceDirect
Aug 21, 2009 · Phosphorylated LAT recruits a number of signaling molecules to the plasma membrane, including PLC-γ1, Grb2, Grap, Gads-SLP76, Vav, Cbl, and the regulatory subunit …
Negative feedback loop in T‐cell activation through …
Jun 10, 2004 · We have developed an expression screening method to detect in vivo substrates of MAPKs in mammalian cells, and identified a membrane protein, linker for activation of T …
Lck promotes Zap70-dependent LAT phosphorylation by bridging ... - PubMed
We report the discovery of a conserved proline-rich motif in LAT that mediates efficient LAT phosphorylation. Lck associates with this motif via its SH3 domain, and with phospho-Zap70 …