Nov 30, 2012 · Our data reveal the major role for HDAC1 in mediating deacetylation, chromatin compaction, and gene silencing in the multigenic domain, and an auxiliary role for HDAC3 that is required for retention of the domain at the lamina.

Jan 31, 2019 · Class I HDACs, encompassing HDAC1, HDAC2, HDAC3, and HDAC8, are ubiquitously expressed and are mainly localized within the nucleus, where they deacetylate diverse histone residues to modulate transcription and …

Jun 23, 2023 · NUP98’s chromatin binding sites are co-occupied by HDAC1. HDAC inhibition diminishes NUP98’s chromatin binding and dysregulates NUP98 and RAE1’s target gene expression. Interestingly, HDAC...

The in vivo physical interaction of lamin A with RBBP4, RBBP7 and HDAC1 observed here, and previously suggested by biochemical fractionation 19, points towards a regulatory role for the nuclear lamina in the function of the NURD complex in normal cells.

May 11, 2021 · HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate proteins.

Apr 1, 2013 · In Drosophila, Lamin B has been shown to be involved in the transcriptional repression of multigenic regions located at the nuclear periphery through histone deacetylation by HDAC1. In vivo, HDAC1 is found in a variety of complexes that are thought to add specificity and efficacy to its function.

Dec 11, 2013 · Our data reveal a crucial function of HDAC1/HDAC2 in the control of lineage specificity and a novel role of HDAC1 as a tumour suppressor in the epidermis. Keywords: chromatin, epidermis, HDACs. The skin is the largest organ of the mammalian body, forming a physical barrier against the environment.

Hdac1 is a major nuclear HDAC controlling IL-1β-dependent inflammatory response in IEC, notably by regulating gene-specific transcriptional responses. Hdac1 may be important in restricting basal and inflammatory-induced gene levels to defined ranges of expression.

Nov 30, 2012 · Our data reveal the major role for HDAC1 in mediating deacetylation, chromatin compaction, and gene silencing in the multigenic domain, and an auxiliary role for HDAC3 that is required for retention of the domain at the lamina.

HDAC1 and 2 are components of corepressor complexes, which function with lysine acetyltransferases to catalyze dynamic protein acetylation and regulate gene expression. In this study, we show that HDAC1 and 2 associate with F-actin in mitotic cells.